Patients with psoriasis have a higher risk of schizophrenia: A systematic review and meta-analysis of observational studies.
Meta-analysis
psoriasis
risk factor
schizophrenia
Journal
Journal of postgraduate medicine
ISSN: 0972-2823
Titre abrégé: J Postgrad Med
Pays: India
ID NLM: 2985196R
Informations de publication
Date de publication:
Historique:
pubmed:
7
6
2019
medline:
23
7
2020
entrez:
7
6
2019
Statut:
ppublish
Résumé
Patients with psoriasis are known to be at a higher risk of several comorbidities, but little is known about their risk of developing schizophrenia. A systematic review and meta-analysis of cohort and case-control studies that reported relative risk, hazard ratio, odds ratio (OR), or standardized incidence ratio comparing risk of schizophrenia in patients with psoriasis versus subjects without psoriasis was conducted. Pooled OR and 95% confidence interval were calculated using random-effect, generic inverse-variance methods of DerSimonian and Laird. A total of five studies (one retrospective cohort study and four case-control studies) with more than 6 million participants met the eligibility criteria and were included in this meta-analysis. The pooled OR of schizophrenia in patients with psoriasis versus subjects without psoriasis was 1.41 (95% confidence interval, 1.19-1.66). The statistical heterogeneity was low with an I2 of 33%. This systematic review and meta-analysis demonstrated a significantly increased risk of schizophrenia among patients with psoriasis.
Sections du résumé
Background and Objectives
Patients with psoriasis are known to be at a higher risk of several comorbidities, but little is known about their risk of developing schizophrenia.
Methods
A systematic review and meta-analysis of cohort and case-control studies that reported relative risk, hazard ratio, odds ratio (OR), or standardized incidence ratio comparing risk of schizophrenia in patients with psoriasis versus subjects without psoriasis was conducted. Pooled OR and 95% confidence interval were calculated using random-effect, generic inverse-variance methods of DerSimonian and Laird.
Results
A total of five studies (one retrospective cohort study and four case-control studies) with more than 6 million participants met the eligibility criteria and were included in this meta-analysis. The pooled OR of schizophrenia in patients with psoriasis versus subjects without psoriasis was 1.41 (95% confidence interval, 1.19-1.66). The statistical heterogeneity was low with an I2 of 33%.
Conclusion
This systematic review and meta-analysis demonstrated a significantly increased risk of schizophrenia among patients with psoriasis.
Identifiants
pubmed: 31169131
pii: 259183
doi: 10.4103/jpgm.JPGM_253_18
pmc: PMC6659437
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
141-145Déclaration de conflit d'intérêts
There are no conflicts of interest.
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