Universal Transform or Multiple Functionality? Understanding the Contribution of the Human Cerebellum across Task Domains.
cerebellum
cognition
fMRI
functional magnetic resonance imaging
review
universal transform
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
05 06 2019
05 06 2019
Historique:
received:
14
11
2018
revised:
10
04
2019
accepted:
11
04
2019
entrez:
7
6
2019
pubmed:
7
6
2019
medline:
24
3
2020
Statut:
ppublish
Résumé
An impressive body of research over the past 30 years has implicated the human cerebellum in a broad range of functions, including motor control, perception, language, working memory, cognitive control, and social cognition. The relatively uniform anatomy and physiology of the cerebellar cortex has given rise to the idea that this structure performs the same computational function across diverse domains. Here we highlight evidence from the human neuroimaging literature that documents the striking functional heterogeneity of the cerebellum, both in terms of task-evoked activity patterns and, as measured under task-free conditions, functional connectivity with the neocortex. Building on these observations, we discuss the theoretical challenges these results present to the idea of a universal cerebellar computation and consider the alternative concept of multiple functionality, the idea that the same underlying circuit implements functionally distinct computations.
Identifiants
pubmed: 31170400
pii: S0896-6273(19)30378-2
doi: 10.1016/j.neuron.2019.04.021
pmc: PMC6686189
mid: NIHMS1530513
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
918-928Subventions
Organisme : NINDS NIH HHS
ID : R01 NS092079
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105839
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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