Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder.
Brodmann area 10
Cognition
Frontal pole
Functional MRI
Future-thinking
Major depressive disorder
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
01
2019
revised:
27
04
2019
accepted:
25
05
2019
pubmed:
7
6
2019
medline:
1
7
2020
entrez:
7
6
2019
Statut:
ppublish
Résumé
Pessimistic thinking about the future is one of the cardinal symptoms of major depressive disorder (MDD) and is an important domain of cognitive functioning associated with hopelessness. Neuroimaging studies have shown that the frontopolar cortex (Brodmann area [BA] 10) is involved in thinking about the future and demonstrated that patients with MDD have dysfunctions in BA10. However, the relationship between pessimistic thinking about the future and brain activity is unclear. Hence, we aimed to compare brain activity during future-thinking between patients with MDD and healthy individuals. We assessed 23 patients with current MDD and 23 healthy individuals. Participants were instructed to imagine the future or to recall the past using the future-thinking paradigm with four distinct temporal conditions (distant future, near future, distant past, and near past) during functional MRI. Resting-state functional MRI was also performed to explore the functional connectivity of BA10. Compared with healthy individuals, patients with MDD had greater negative thinking about the distant future and exhibited increased activation in the medial BA10 when imagining the distant future, following small-volume correction focusing on the frontopolar a priori region of interest (family-wise error correction p < 0.05). Increased positive functional correlation between the right BA10 seed region and the posterior cingulate cortex was also observed. Patients with MDD who show greater pessimistic thinking about the distant future demonstrate increased activation in the frontopolar cortex. These findings are consistent with the hypothesis that frontopolar cortical dysfunction plays a key role in the hopelessness that manifests in patients with MDD.
Sections du résumé
BACKGROUND
Pessimistic thinking about the future is one of the cardinal symptoms of major depressive disorder (MDD) and is an important domain of cognitive functioning associated with hopelessness. Neuroimaging studies have shown that the frontopolar cortex (Brodmann area [BA] 10) is involved in thinking about the future and demonstrated that patients with MDD have dysfunctions in BA10. However, the relationship between pessimistic thinking about the future and brain activity is unclear. Hence, we aimed to compare brain activity during future-thinking between patients with MDD and healthy individuals.
METHODS
We assessed 23 patients with current MDD and 23 healthy individuals. Participants were instructed to imagine the future or to recall the past using the future-thinking paradigm with four distinct temporal conditions (distant future, near future, distant past, and near past) during functional MRI. Resting-state functional MRI was also performed to explore the functional connectivity of BA10.
RESULTS
Compared with healthy individuals, patients with MDD had greater negative thinking about the distant future and exhibited increased activation in the medial BA10 when imagining the distant future, following small-volume correction focusing on the frontopolar a priori region of interest (family-wise error correction p < 0.05). Increased positive functional correlation between the right BA10 seed region and the posterior cingulate cortex was also observed.
CONCLUSION
Patients with MDD who show greater pessimistic thinking about the distant future demonstrate increased activation in the frontopolar cortex. These findings are consistent with the hypothesis that frontopolar cortical dysfunction plays a key role in the hopelessness that manifests in patients with MDD.
Identifiants
pubmed: 31170685
pii: S2213-1582(19)30227-X
doi: 10.1016/j.nicl.2019.101877
pmc: PMC6551553
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101877Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Références
Neuron. 2010 Feb 25;65(4):550-62
pubmed: 20188659
J Consult Clin Psychol. 1974 Dec;42(6):861-5
pubmed: 4436473
Cogn Affect Behav Neurosci. 2018 Jun;18(3):476-484
pubmed: 29557086
Psychiatry Res. 2002 Jul 31;110(3):291-9
pubmed: 12127479
Arch Gen Psychiatry. 2012 Oct;69(10):1014-21
pubmed: 22638494
Am J Psychiatry. 2017 Jun 1;174(6):533-545
pubmed: 28335622
Behav Res Ther. 2018 Mar;102:42-51
pubmed: 29328948
Lancet. 2012 Mar 17;379(9820):1045-55
pubmed: 22189047
J Neurosci. 2011 May 4;31(18):6771-9
pubmed: 21543607
Nat Rev Neurosci. 2016 Nov;17(11):718-731
pubmed: 27654862
Ann N Y Acad Sci. 2008 Mar;1124:161-80
pubmed: 18400930
Am J Psychiatry. 2008 Aug;165(8):969-77
pubmed: 18628348
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4259-64
pubmed: 11259662
Biol Psychiatry. 2003 Sep 1;54(5):573-83
pubmed: 12946886
Neuropsychologia. 2014 Dec;65:41-55
pubmed: 25447064
Neuroimage. 2008 Mar 1;40(1):398-407
pubmed: 18164213
Neuroimage. 2010 Dec;53(4):1359-67
pubmed: 20654722
Neuroimage. 2003 Aug;19(4):1369-80
pubmed: 12948695
Nat Rev Neurosci. 2007 Sep;8(9):657-61
pubmed: 17700624
Brain Cogn. 2016 Oct;108:32-41
pubmed: 27429096
Int Clin Psychopharmacol. 2008 May;23(3):120-9
pubmed: 18408526
Trends Cogn Sci. 2007 Jul;11(7):290-8
pubmed: 17548231
Br J Clin Psychol. 1998 Nov;37(4):371-9
pubmed: 9856290
Neuropsychologia. 2007 Apr 8;45(7):1363-77
pubmed: 17126370
Psychiatry Res. 2007 Sep 30;153(1):61-7
pubmed: 17445908
Cereb Cortex. 2007 Oct;17(10):2346-53
pubmed: 17190970
J Abnorm Psychol. 1978 Feb;87(1):49-74
pubmed: 649856
Conscious Cogn. 2013 Sep;22(3):898-912
pubmed: 23810864
Soc Cogn Affect Neurosci. 2014 Apr;9(4):487-93
pubmed: 23327934
Q J Exp Psychol (Hove). 2015;68(1):192-204
pubmed: 25191929
JAMA Psychiatry. 2015 Jun;72(6):603-11
pubmed: 25785575
Br J Clin Psychol. 2004 Jun;43(Pt 2):129-142
pubmed: 15169614
Nat Rev Neurosci. 2003 Feb;4(2):139-47
pubmed: 12563285
Soc Cogn Affect Neurosci. 2009 Dec;4(4):313-27
pubmed: 19620180
Hum Brain Mapp. 2015 Aug;36(8):2928-47
pubmed: 25931002
Am J Psychiatry. 2013 Feb;170(2):197-206
pubmed: 23223803
Soc Cogn Affect Neurosci. 2014 Dec;9(12):1942-51
pubmed: 24493844
J Affect Disord. 2017 Aug 15;218:210-216
pubmed: 28477499
J Affect Disord. 2012 Jan;136(1-2):e1-e11
pubmed: 21185083
Nat Rev Neurosci. 2017 Nov;18(11):645-657
pubmed: 28951610
Arch Gen Psychiatry. 1963 Oct;9:324-33
pubmed: 14045261
Curr Opin Behav Sci. 2017 Oct;17:41-50
pubmed: 29130061
Am J Psychiatry. 2017 Apr 1;174(4):378-386
pubmed: 27771973