Ion-Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules.
Solomon link
intertwined molecules
ion-mobility spectrometry
tandem mass spectrometry
trefoil knot
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
12 08 2019
12 08 2019
Historique:
received:
12
04
2019
pubmed:
8
6
2019
medline:
8
6
2019
entrez:
8
6
2019
Statut:
ppublish
Résumé
A rapid screening method based on traveling-wave ion-mobility spectrometry (TWIMS) combined with tandem mass spectrometry provides insight into the topology of interlocked and knotted molecules, even when they exist in complex mixtures, such as interconverting dynamic combinatorial libraries. A TWIMS characterization of structure-indicative fragments generated by collision-induced dissociation (CID) together with a floppiness parameter defined based on parent- and fragment-ion arrival times provide a straightforward topology identification. To demonstrate its broad applicability, this approach is applied here to six Hopf and two Solomon links, a trefoil knot, and a [3]catenate.
Identifiants
pubmed: 31173448
doi: 10.1002/anie.201904541
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11324-11328Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC 765
Pays : International
Organisme : Alexander von Humboldt-Stiftung
ID : Postdoc Fellowship
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : PZ00P2_161270
Pays : International
Organisme : H2020 European Research Council
ID : 695009
Pays : International
Organisme : UK Engineering and Pysical Sciences Research Council
ID : EP/P027067/1
Pays : International
Organisme : Fondation Philippe Wiener - Maurice Anspach
ID : Postdoc Fellowship
Pays : International
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.