Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw.

biomaterials biomineralization bisphosphonate-related osteonecrosis of the jaw cellular biology gingival fibroblasts osteonecrosis zoledronate

Journal

Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929

Informations de publication

Date de publication:
06 Jun 2019
Historique:
received: 14 05 2019
revised: 03 06 2019
accepted: 04 06 2019
entrez: 9 6 2019
pubmed: 9 6 2019
medline: 9 6 2019
Statut: epublish

Résumé

(1) Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most often seen side effects in patients treated with nitrogen-containing bisphosphonates (BPs), a post-surgical non-healing wound condition. Since calcium phosphate (CP) compounds are able to adsorb zoledronate (ZOL) when used as a drug delivery vehicle, we aimed to verify if these ceramics might have a potential protective effect for soft tissues surrounding surgical osseous wounds. (2) Methods: The chemical reaction between ZOL and CP compounds was evaluated through ultraviolet-visible spectroscopy and elemental analysis. A primary culture of human gingival fibroblasts (HGF) was established as a model to evaluate the cytotoxicity of the association of ZOL (5-500 μM) and of ZOL/biphasic calcium phosphates (BCP). Metabolic activity, cell viability, types of cell death, the cell cycle through, and the migration ability of human gingival fibroblasts were evaluated. (3) Results: ZOL was adsorbed by biphasic calcium phosphate compounds in an aqueous solution. The HGF were sensitive to ZOL toxicity; nevertheless, ZOL/BCP showed a significant protective effect regarding metabolic activity, cell viability, and cell migration. (4) Conclusions: BCP interaction with ZOL reduces or abolishes its toxicity in HGF. This finding represents a potential solution for BRONJ in the case of patients undergoing therapy with ZOL.

Identifiants

DOI: 10.3390/ma12111840 PMID: 31174333 PMC: PMC6601279
pubmed: 31174333
pii: ma12111840
doi: 10.3390/ma12111840
pmc: PMC6601279
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : FCT, COMPETE-FEDER
ID : PEst-C/SAU/UI3282/2013 and UID/NEU/04539/2013

Références

Cancer Res. 2000 Nov 1;60(21):6001-7
pubmed: 11085520
Lasers Surg Med. 2001;29(2):179-84
pubmed: 11553908
J Periodontol. 1992 Sep;63(9):729-35
pubmed: 1335498
J Mater Sci Mater Med. 2003 Mar;14(3):195-200
pubmed: 15348464
Nat Protoc. 2006;1(3):1112-6
pubmed: 17406391
Nat Protoc. 2007;2(2):329-33
pubmed: 17406593
J Oral Pathol Med. 2007 Jul;36(6):319-28
pubmed: 17559492
J Mol Histol. 2008 Feb;39(1):37-47
pubmed: 17786573
Osteoporos Int. 2008 Jun;19(6):733-59
pubmed: 18214569
Folia Histochem Cytobiol. 2008;46(1):117-9
pubmed: 18296274
Oral Dis. 2008 Apr;14(3):277-85
pubmed: 18336375
J Oral Maxillofac Surg. 2008 May;66(5):839-47
pubmed: 18423269
Mayo Clin Proc. 2008 Sep;83(9):1032-45
pubmed: 18775204
Clin Oral Investig. 2010 Feb;14(1):35-41
pubmed: 19294435
Bone. 2009 Nov;45(5):843-52
pubmed: 19631301
J Dent Res. 2010 Jan;89(1):40-5
pubmed: 19948943
J Orofac Orthop. 2009 Sep;70(5):351-62
pubmed: 19997994
Fibrogenesis Tissue Repair. 2010 Apr 01;3:6
pubmed: 20359336
Acta Crystallogr C. 2010 Jun;66(Pt 6):m166-70
pubmed: 20522941
Drug Discov Today. 2010 Jul;15(13-14):547-52
pubmed: 20546919
Curr Pharm Des. 2010;16(27):2950-60
pubmed: 20722616
J Oral Maxillofac Surg. 2010 Nov;68(11):2837-45
pubmed: 20971371
Arch Oral Biol. 2011 May;56(5):491-8
pubmed: 21146154
Naunyn Schmiedebergs Arch Pharmacol. 2011 Mar;383(3):297-308
pubmed: 21225243
Clin Oral Investig. 2012 Feb;16(1):87-93
pubmed: 21225298
J Dent Res. 2011 Jun;90(6):810-6
pubmed: 21427353
J Vis Exp. 2011 Apr 24;(50):null
pubmed: 21540825
Nat Rev Cancer. 2011 Jun;11(6):411-25
pubmed: 21593787
Bone. 2011 Oct;49(4):710-6
pubmed: 21807133
Biomaterials. 2012 Jan;33(2):722-30
pubmed: 22014461
J Craniomaxillofac Surg. 2012 Dec;40(8):e229-35
pubmed: 22082730
Acta Biomater. 2012 Apr;8(4):1401-21
pubmed: 22127225
Arch Oral Biol. 2012 Jul;57(7):906-17
pubmed: 22172403
Tissue Eng Part B Rev. 2012 Oct;18(5):323-40
pubmed: 22440082
Eur J Med Chem. 2012 Jul;53:398-402
pubmed: 22560315
PLoS One. 2012;7(11):e49232
pubmed: 23155470
J Craniomaxillofac Surg. 2013 Oct;41(7):558-63
pubmed: 23332469
Photodiagnosis Photodyn Ther. 2013 Feb;10(1):51-61
pubmed: 23465373
Braz Dent J. 2013 Nov-Dec;24(6):551-8
pubmed: 24474348
Eur J Med Chem. 2014 May 22;79:273-81
pubmed: 24747064
J Oral Pathol Med. 2014 Oct;43(9):711-21
pubmed: 24762323
J Craniomaxillofac Surg. 2015 Apr;43(3):396-401
pubmed: 25614214
Oncol Rev. 2014 Sep 23;8(2):254
pubmed: 25992241
Curr Protoc Mol Biol. 2015 Jul 01;111:28.6.1-11
pubmed: 26131851
J Maxillofac Oral Surg. 2014 Dec;13(4):386-93
pubmed: 26225001
Int J Cell Biol. 2015;2015:834893
pubmed: 26448760
J Craniomaxillofac Surg. 2016 Mar;44(3):271-8
pubmed: 26805920
Med Oral Patol Oral Cir Bucal. 2016 May 01;21(3):e260-70
pubmed: 26827066
Arch Oral Biol. 2016 May;65:59-65
pubmed: 26854621
J Bone Oncol. 2012 Dec 11;2(1):47-57
pubmed: 26909265
J Bone Oncol. 2013 Feb 09;2(2):70-6
pubmed: 26909273
Cochrane Database Syst Rev. 2016 Feb 26;2:CD008455
pubmed: 26919630
Adv Wound Care (New Rochelle). 2016 Mar 1;5(3):119-136
pubmed: 26989578
Acta Biomater. 2016 Sep 15;42:400-410
pubmed: 27326918
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Jan;123(1):8-19
pubmed: 27727104
Braz Oral Res. 2016 Nov 28;30(1):e122
pubmed: 27901204
Med Oral Patol Oral Cir Bucal. 2017 Mar 1;22(2):e177-e184
pubmed: 28160593
ACS Med Chem Lett. 2017 Feb 22;8(3):310-315
pubmed: 28337322
Clin Oral Investig. 2018 Mar;22(2):893-900
pubmed: 28688093
Eur J Med Chem. 2018 Feb 25;146:395-408
pubmed: 29407966
Cancers (Basel). 2018 Jun 27;10(7):null
pubmed: 29954079
Bone Rep. 2018 Mar 15;8:104-109
pubmed: 29955628
J Int Med Res. 2018 Oct;46(10):4277-4296
pubmed: 30091399
J Oral Biosci. 2019 Jun;61(2):99-104
pubmed: 31109863
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
pubmed: 6606682
Curr Opin Cell Biol. 1994 Dec;6(6):872-6
pubmed: 7880536

Auteurs

Siri Paulo (S)

Institute of Endodontics, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. sirivpaulo@gmail.com.
ORCID: 0000-0002-3914-2423

Mafalda Laranjo (M)

Biophysics Institute, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. mafaldalaranjo@gmail.com.
ORCID: 0000-0003-0689-6007

Ana M Abrantes (AM)

Biophysics Institute, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. mabrantes@fmed.uc.pt.

João Casalta-Lopes (J)

Biophysics Institute, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. joao.casalta@gmail.com.
Radiation Oncology Department, Coimbra University Hospital Center, 3000-548 Coimbra, Portugal. joao.casalta@gmail.com.

Kathleen Santos (K)

Biophysics Institute, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. kathleen.santos@hotmail.com.

Ana C Gonçalves (AC)

Applied Molecular Biology Unit, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. acc.goncalves@gmail.com.

Anabela Baptista Paula (AB)

Institute of Integrated Clinical Practice, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. anabelabppaula@sapo.pt.
ORCID: 0000-0001-6154-4173

Carlos Miguel Marto (CM)

Institute Experimental Pathology, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. mig-marto@hotmail.com.
ORCID: 0000-0001-9269-5417

Ana Bela Sarmento-Ribeiro (AB)

Applied Molecular Biology Unit, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. absarmento@fmed.uc.pt.

Eunice Carrilho (E)

Institute of Integrated Clinical Practice, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. eunicecarrilho@gmail.com.
ORCID: 0000-0002-5759-5557

Arménio Serra (A)

Department of Chemical Engineering, Faculty of Science and Technology University of Coimbra, Polo II, Pinhal de Marrocos, 3030-790 Coimbra, Portugal. armenio.serra@gmail.com.

Maria F Botelho (MF)

Biophysics Institute, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. mfbotelho@fmed.uc.pt.

Manuel M Ferreira (MM)

Institute of Endodontics, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. m.mferreira@netcabo.pt.
ORCID: 0000-0002-5968-6161

Classifications MeSH