Comparison of mRNA expression profiles of drug-metabolizing enzymes and transporters in fresh and cryopreserved cynomolgus monkey hepatocytes.

3T3 Cells Alanine Transaminase / genetics Animals Aspartate Aminotransferases / genetics Cell Survival Cells, Cultured Cryopreservation Female Gene Expression Profiling Hepatocytes / metabolism L-Lactate Dehydrogenase / genetics Macaca fascicularis Male Mice RNA, Messenger / genetics Real-Time Polymerase Chain Reaction gamma-Glutamyltransferase / genetics
Co-culture Cynomolgus monkey Drug-metabolizing enzymes Hepatocytes Monolayer Spheroid Transporters mRNA expression profiles

Journal

Drug metabolism and pharmacokinetics
ISSN: 1880-0920
Titre abrégé: Drug Metab Pharmacokinet
Pays: England
ID NLM: 101164773

Informations de publication

Date de publication:
Aug 2019
Historique:
received: 17 06 2018
revised: 12 03 2019
accepted: 05 04 2019
pubmed: 9 6 2019
medline: 6 2 2020
entrez: 9 6 2019
Statut: ppublish

Résumé

In this study, freshly isolated and cryopreserved cynomolgus monkey hepatocytes were seeded on Cell-able

Identifiants

DOI: 10.1016/j.dmpk.2019.04.003 PMID: 31174977
pubmed: 31174977
pii: S1347-4367(18)30101-0
doi: 10.1016/j.dmpk.2019.04.003
pii:
doi:

Substances chimiques

RNA, Messenger 0
L-Lactate Dehydrogenase EC 1.1.1.27
gamma-Glutamyltransferase EC 2.3.2.2
Aspartate Aminotransferases EC 2.6.1.1
Alanine Transaminase EC 2.6.1.2

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

253-263

Informations de copyright

Copyright © 2019. Published by Elsevier Ltd.

Auteurs

Akiko Koeda (A)

Ina Research Inc., Ina, Japan; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: a-koeda@ina-research.co.jp.

Takahiro Iwao (T)

Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: tiwao@phar.nagoya-cu.ac.jp.

Anna Nakanishi (A)

Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: c132540@yahoo.co.jp.

Shota Mizuno (S)

Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: shota9117529@gmail.com.

Misaki Yamashita (M)

Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: misaki47kumagirl@gmail.com.

Yoko Sakai (Y)

Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: yoko0309@phar.nagoya-cu.ac.jp.

Katsunori Nakamura (K)

Department of Pharmacy, Ryukyu University Hospital, Okinawa, Japan. Electronic address: nkatsu@med.u-ryukyu.ac.jp.

Tamihide Matsunaga (T)

Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: tmatsu@phar.nagoya-cu.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Alanine transaminase › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Eucaryotes › Animaux › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Aspartate aminotransferases › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Cellules › Cellules cultivées › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Techniques d'investigation › Conservation biologique › Cryoconservation › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › L-Lactate dehydrogenase › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca fascicularis › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques d'amplification d'acides nucléiques › Réaction de polymérisation en chaîne › Réaction de polymérisation en chaine en temps réel › Comparison of mRNA expression profiles of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Aminoacyltransferases › gamma-Glutamyltransferase › Comparison of mRNA expression profiles of...