Differential Effect of Glucose on ER-Mitochondria Ca
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
15
10
2018
accepted:
04
06
2019
pubmed:
9
6
2019
medline:
21
3
2020
entrez:
9
6
2019
Statut:
ppublish
Résumé
Glucotoxicity-induced β-cell dysfunction in type 2 diabetes is associated with alterations of mitochondria and the endoplasmic reticulum (ER). Both organelles interact at contact sites, defined as mitochondria-associated membranes (MAMs), which were recently implicated in the regulation of glucose homeostasis. The role of MAMs in β-cells is still largely unknown, and their implication in glucotoxicity-associated β-cell dysfunction remains to be defined. Here, we report that acute glucose treatment stimulated ER-mitochondria interactions and calcium (Ca
Identifiants
pubmed: 31175102
pii: db18-1112
doi: 10.2337/db18-1112
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1778-1794Informations de copyright
© 2019 by the American Diabetes Association.