Polygenic risk associated with post-traumatic stress disorder onset and severity.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
07 06 2019
07 06 2019
Historique:
received:
11
04
2019
accepted:
07
05
2019
entrez:
9
6
2019
pubmed:
9
6
2019
medline:
7
2
2020
Statut:
epublish
Résumé
Post-traumatic stress disorder (PTSD) is a psychiatric illness with a highly polygenic architecture without large effect-size common single-nucleotide polymorphisms (SNPs). Thus, to capture a substantial portion of the genetic contribution, effects from many variants need to be aggregated. We investigated various aspects of one such approach that has been successfully applied to many traits, polygenic risk score (PRS) for PTSD. Theoretical analyses indicate the potential prediction ability of PRS. We used the latest summary statistics from the largest published genome-wide association study (GWAS) conducted by Psychiatric Genomics Consortium for PTSD (PGC-PTSD). We found that the PRS constructed for a cohort comprising veterans of recent wars (n = 244) explains a considerable proportion of PTSD onset (Nagelkerke R
Identifiants
pubmed: 31175274
doi: 10.1038/s41398-019-0497-3
pii: 10.1038/s41398-019-0497-3
pmc: PMC6555815
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
165Investigateurs
Rasha Hammamieh
(R)
Aarti Gautam
(A)
Ruoting Yang
(R)
Bernie J Daigle
(BJ)
Leroy Hood
(L)
Kai Wang
(K)
Inyoul Lee
(I)
Synthia H Mellon
(SH)
Owen M Wolkowitz
(OM)
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