Structural and functional consequences of the STAT5B


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
07 06 2019
Historique:
received: 30 09 2018
accepted: 10 05 2019
entrez: 9 6 2019
pubmed: 9 6 2019
medline: 18 6 2019
Statut: epublish

Résumé

Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5B

Identifiants

pubmed: 31175292
doi: 10.1038/s41467-019-10422-7
pii: 10.1038/s41467-019-10422-7
pmc: PMC6555848
doi:

Substances chimiques

STAT5 Transcription Factor 0
STAT5B protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Pagination

2517

Subventions

Organisme : Austrian Science Fund FWF
ID : I 4157
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : I 4218
Pays : Austria

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Auteurs

Elvin D de Araujo (ED)

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.

Fettah Erdogan (F)

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.

Heidi A Neubauer (HA)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.

Deniz Meneksedag-Erol (D)

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Department of Physics, University of Toronto, 60 St. George Street, Toronto, ON, M5S 1A7, Canada.

Pimyupa Manaswiyoungkul (P)

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.

Mohammad S Eram (MS)

Dalriada Drug Discovery, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.

Hyuk-Soo Seo (HS)

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.

Abdul K Qadree (AK)

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.

Johan Israelian (J)

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.

Anna Orlova (A)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.

Tobias Suske (T)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.

Ha T T Pham (HTT)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.

Auke Boersma (A)

Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.

Simone Tangermann (S)

Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.

Lukas Kenner (L)

Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.
Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
Clinical Institute of Pathology, Department for Experimental and Laboratory Animal Pathology, Medical University of Vienna, 1090, Vienna, Austria.

Thomas Rülicke (T)

Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.

Aiping Dong (A)

Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada.

Manimekalai Ravichandran (M)

Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada.

Peter J Brown (PJ)

Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada.

Gerald F Audette (GF)

Department of Chemistry, York University, 327C Life Sciences Building, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada.

Sarah Rauscher (S)

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.
Department of Physics, University of Toronto, 60 St. George Street, Toronto, ON, M5S 1A7, Canada.

Sirano Dhe-Paganon (S)

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. dhepag@crystal.harvard.edu.
Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA. dhepag@crystal.harvard.edu.

Richard Moriggl (R)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria. richard.moriggl@vetmeduni.ac.at.
Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria. richard.moriggl@vetmeduni.ac.at.
Medical University of Vienna, 1090, Vienna, Austria. richard.moriggl@vetmeduni.ac.at.

Patrick T Gunning (PT)

Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada. patrick.gunning@utoronto.ca.
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada. patrick.gunning@utoronto.ca.

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Classifications MeSH