Grape Seed Proanthocyanidin Affects Lipid Metabolism via Changing Gut Microflora and Enhancing Propionate Production in Weaned Pigs.

Animals Female Gastrointestinal Microbiome / drug effects Grape Seed Extract / pharmacology Lipid Metabolism / drug effects Male Proanthocyanidins / pharmacology Propionates / metabolism Swine Weaning
grape seed proanthocyanidin gut microbiota lipid metabolism pigs propionate

Journal

The Journal of nutrition
ISSN: 1541-6100
Titre abrégé: J Nutr
Pays: United States
ID NLM: 0404243

Informations de publication

Date de publication:
01 09 2019
Historique:
received: 08 10 2018
revised: 26 11 2018
accepted: 25 04 2019
pubmed: 9 6 2019
medline: 20 6 2020
entrez: 9 6 2019
Statut: ppublish

Résumé

It is not clear whether dietary grape seed proanthocyanidin (GSP) affects mammalian lipid metabolism via the gut microbiota. The aim of this study was to evaluate the contribution of the gut microbiota to the effect of dietary GSP. This study was divided into 3 separate experiments using Duroc × Landrace × Yorkshire pigs (50% male) weaned at day 28 and then fed the same basal diet (NC). In Experiment 1, 90 pigs were fed NC or NC with 250 mg GSP/kg (GSP) or 400 mg betaine/kg [positive control (PC)] for 28 d. In Experiment 2, 30 pigs were fed NC, GSP, or GSP with antibiotics (GSP + Abx) diets for 14 d. In Experiment 3, pigs were fed NC, NC plus 1 g sodium propionate/kg (SP), or NC plus 1 g sodium butyrate/kg (SB) diet for 14 d. Serum biochemical indexes, SCFA concentrations, and microbial composition were determined. In Experiment 1, compared with the GSP group, visceral adipocyte area was higher in the NC (28.6%) and PC (18.2%) groups (P ≤ 0.05). Colonic propionate and butyrate concentrations were 30.2% and 3.6% higher in the GSP group than in the NC group, respectively (P ≤ 0.05). In Experiment 2, compared with the GSP group, the NC group had a 108% higher Firmicutes to Bacteroidetes ratio and had 50.4%, 61.2%, and 82.3% lower abundance of Akkermansia, Alistipes, and Bacteroides, respectively (P ≤ 0.05); antibiotics removed these effects of GSP. In Experiment 3, serum peptide YY was 19.5% higher in the SP group than in the NC group (P ≤ 0.05), and it did not differ between the SB and NC groups (P > 0.05). GSP affected lipid metabolism in weaned pigs, which is associated with changed gut microbiota and enhanced microbial propionate production. These findings provide potential mechanisms for GSP intake to improve lipid metabolism.

Sections du résumé

BACKGROUND
It is not clear whether dietary grape seed proanthocyanidin (GSP) affects mammalian lipid metabolism via the gut microbiota.
OBJECTIVE
The aim of this study was to evaluate the contribution of the gut microbiota to the effect of dietary GSP.
METHODS
This study was divided into 3 separate experiments using Duroc × Landrace × Yorkshire pigs (50% male) weaned at day 28 and then fed the same basal diet (NC). In Experiment 1, 90 pigs were fed NC or NC with 250 mg GSP/kg (GSP) or 400 mg betaine/kg [positive control (PC)] for 28 d. In Experiment 2, 30 pigs were fed NC, GSP, or GSP with antibiotics (GSP + Abx) diets for 14 d. In Experiment 3, pigs were fed NC, NC plus 1 g sodium propionate/kg (SP), or NC plus 1 g sodium butyrate/kg (SB) diet for 14 d. Serum biochemical indexes, SCFA concentrations, and microbial composition were determined.
RESULTS
In Experiment 1, compared with the GSP group, visceral adipocyte area was higher in the NC (28.6%) and PC (18.2%) groups (P ≤ 0.05). Colonic propionate and butyrate concentrations were 30.2% and 3.6% higher in the GSP group than in the NC group, respectively (P ≤ 0.05). In Experiment 2, compared with the GSP group, the NC group had a 108% higher Firmicutes to Bacteroidetes ratio and had 50.4%, 61.2%, and 82.3% lower abundance of Akkermansia, Alistipes, and Bacteroides, respectively (P ≤ 0.05); antibiotics removed these effects of GSP. In Experiment 3, serum peptide YY was 19.5% higher in the SP group than in the NC group (P ≤ 0.05), and it did not differ between the SB and NC groups (P > 0.05).
CONCLUSIONS
GSP affected lipid metabolism in weaned pigs, which is associated with changed gut microbiota and enhanced microbial propionate production. These findings provide potential mechanisms for GSP intake to improve lipid metabolism.

Identifiants

DOI: 10.1093/jn/nxz102 PMID: 31175811
pubmed: 31175811
pii: S0022-3166(22)16719-2
doi: 10.1093/jn/nxz102
doi:

Substances chimiques

Grape Seed Extract 0
Grape Seed Proanthocyanidins 0
Proanthocyanidins 0
Propionates 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1523-1532

Informations de copyright

Copyright © American Society for Nutrition 2019.

Auteurs

Yi Wu (Y)

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Ning Ma (N)

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Peixia Song (P)

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Ting He (T)

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Crystal Levesque (C)

Department of Animal Science, College of Agriculture and Biological Sciences, South Dakota State University, Brookings, SD, USA.

Yueyu Bai (Y)

Animal Health Supervision of Henan Province, Breeding Animal Genetic Performance Measurement Center of Henan Province, Zhengzhou, Henan, China.

Aizhong Zhang (A)

College of Animal Science & Veterinary Medicine, Heilongjiang Bayi Agricultural University, Heilongjiang, Daqing, China.

Xi Ma (X)

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Department of Internal Medicine and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Grape Seed Proanthocyanidin Affects Lipid...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Grape Seed Proanthocyanidin Affects Lipid...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Extrait de pépins de raisin › Grape Seed Proanthocyanidin Affects Lipid...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Grape Seed Proanthocyanidin Affects Lipid...
questionsmedicales.fr › Structures macromoléculaires › Tanins › Proanthocyanidines › Grape Seed Proanthocyanidin Affects Lipid...
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Propionates › Grape Seed Proanthocyanidin Affects Lipid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Grape Seed Proanthocyanidin Affects Lipid...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Sevrage › Grape Seed Proanthocyanidin Affects Lipid...