CID-6033590 inhibits p38MAPK pathway and induces S-phase cell cycle arrest and apoptosis in DU145 and PC-3 cells.
Animals
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Catalase
/ metabolism
Cell Cycle Checkpoints
/ drug effects
Cell Line
Glutathione
/ metabolism
Humans
Hydrazones
/ pharmacology
Male
Mice, Inbred BALB C
Prostatic Neoplasms
/ drug therapy
Protein Kinase Inhibitors
/ pharmacology
Reactive Oxygen Species
/ metabolism
S Phase
/ drug effects
Superoxide Dismutase
/ metabolism
p38 Mitogen-Activated Protein Kinases
/ antagonists & inhibitors
Apoptosis
CID-6033590
Prostate cancer
S-phase arrest
Sulfonylhydrazide
p38MAPK
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
04
01
2019
revised:
08
03
2019
accepted:
04
06
2019
pubmed:
9
6
2019
medline:
25
1
2020
entrez:
9
6
2019
Statut:
ppublish
Résumé
Metastatic prostate cancer, with no effective treatment, is among the leading causes of cancer-associated deaths in men. Overexpression of p38αMAPK has been observed in neuroendocrine prostate cancer patients and in both DU145 and PC-3 cell lines and represents a good drug target. Sulfonamide derivatives have shown biological activities against many human diseases, including cancer. CID-6033590, a sulfonylhydrazide compound, screened from PubChem database by molecular docking with p38αMAPK, was evaluated for anti-cancerous activities. CID-6033590 induced toxicity in both DU145 and PC-3 cells in a concentration and time-dependent manner with an IC
Identifiants
pubmed: 31175925
pii: S0887-2333(19)30009-8
doi: 10.1016/j.tiv.2019.06.003
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Hydrazones
0
Protein Kinase Inhibitors
0
Reactive Oxygen Species
0
Catalase
EC 1.11.1.6
Superoxide Dismutase
EC 1.15.1.1
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
420-436Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.