Copper trafficking in eukaryotic systems: current knowledge from experimental and computational efforts.
Journal
Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
10
03
2019
revised:
16
04
2019
accepted:
02
05
2019
pubmed:
9
6
2019
medline:
29
7
2020
entrez:
9
6
2019
Statut:
ppublish
Résumé
Copper plays a vital role in fundamental cellular functions, and its concentration in the cell must be tightly regulated, as dysfunction of copper homeostasis is linked to severe neurological diseases and cancer. This review provides a compendium of current knowledge regarding the mechanism of copper transfer from the blood system to the Golgi apparatus; this mechanism involves the copper transporter hCtr1, the metallochaperone Atox1, and the ATPases ATP7A/B. We discuss key insights regarding the structural and functional properties of the hCtr1-Atox1-ATP7B cycle, obtained from diverse studies relying on distinct yet complementary biophysical, biochemical, and computational methods. We further address the mechanistic aspects of the cycle that continue to remain elusive. These knowledge gaps must be filled in order to be able to harness our understanding of copper transfer to develop therapeutic approaches with the capacity to modulate copper metabolism.
Identifiants
pubmed: 31176065
pii: S0959-440X(19)30023-5
doi: 10.1016/j.sbi.2019.05.002
pmc: PMC6863429
pii:
doi:
Substances chimiques
Copper Transport Proteins
0
Copper
789U1901C5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-33Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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