Electrochemotherapy in Veterinary Oncology: State-of-the-Art and Perspectives.
Biphasic pulses
Bleomycin
Carcinoma
Cisplatin
Electroporation
Mast cell tumor
Pets
Sarcoma
Journal
The Veterinary clinics of North America. Small animal practice
ISSN: 1878-1306
Titre abrégé: Vet Clin North Am Small Anim Pract
Pays: United States
ID NLM: 7809942
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
pubmed:
10
6
2019
medline:
5
9
2019
entrez:
10
6
2019
Statut:
ppublish
Résumé
Tumor microenvironment represents a key obstacle for the effectiveness of anticancer drugs. Electrochemotherapy involves the systemic or local delivery of lipophobic drugs such as bleomycin and cisplatin, with the application of permeabilizing electric pulses having appropriate amplitude and waveforms. This greatly enhances the uptake of these drugs by an estimated factor of 700-fold for bleomycin and 4 to 8 times for cisplatin. Because of its efficacy and limited morbidity, this therapeutic option is becoming more and more available in veterinary oncology either as an adjuvant to surgery or as first line of treatment with palliative or curative purposes.
Identifiants
pubmed: 31176458
pii: S0195-5616(19)30083-X
doi: 10.1016/j.cvsm.2019.04.006
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
967-979Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.