Adjuvant drug-assisted bone healing: Part III - Further strategies for local and systemic modulation.

Adjuvants, Pharmaceutic / pharmacology Bone Regeneration / drug effects Humans
Bisphosphonates Wnt signaling bone metabolism critical-size bone defects small molecules statins strontium

Journal

Clinical hemorheology and microcirculation
ISSN: 1875-8622
Titre abrégé: Clin Hemorheol Microcirc
Pays: Netherlands
ID NLM: 9709206

Informations de publication

Date de publication:
2019
Historique:
pubmed: 10 6 2019
medline: 25 3 2020
entrez: 10 6 2019
Statut: ppublish

Résumé

In this third in a series of reviews on adjuvant drug-assisted bone healing, further approaches aiming at influencing the healing process are discussed. Local and systemic modulation of bone metabolism is pursued with use of a number of drugs with completely different indications, which are characterized by a pleiotropic spectrum of action. These include drugs used to treat lipid disorders (HMG-CoA reductase inhibitors), hypertension (ACE inhibitors), osteoporosis (bisphosphonates), cancer (proteasome inhibitors) and others. Potential applications to enhance bone healing are discussed.

Identifiants

DOI: 10.3233/CH-199104 PMID: 31177207
pubmed: 31177207
pii: CH199104
doi: 10.3233/CH-199104
doi:

Substances chimiques

Adjuvants, Pharmaceutic 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

439-488

Auteurs

Rebecca Rothe (R)

Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.

Sabine Schulze (S)

University Center of Orthopaedics and Traumatology (OUC), University Hospital Carl Gustav Carus, Dresden, Germany.
Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Christin Neuber (C)

Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.

Sandra Hauser (S)

Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.

Stefan Rammelt (S)

University Center of Orthopaedics and Traumatology (OUC), University Hospital Carl Gustav Carus, Dresden, Germany.
Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Center for Regenerative Therapies Dresden (CRTD), Tatzberg 4, Dresden.

Jens Pietzsch (J)

Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.
Technische Universität Dresden, School of Science, Faculty of Chemistry and Food Chemistry, Dresden, Germany.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Excipients pharmaceutiques › Adjuvants pharmaceutiques › Adjuvant drug-assisted bone healing: Part III...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Régénération osseuse › Adjuvant drug-assisted bone healing: Part III...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Adjuvant drug-assisted bone healing: Part III...