Frontal Variant of Alzheimer's Disease: A Report of a Novel PSEN1 Mutation.

Alzheimer Disease / diagnostic imaging Atrophy / diagnostic imaging Female Frontal Lobe / diagnostic imaging Humans Magnetic Resonance Imaging Middle Aged Mutation Presenilin-1 / genetics
Behavioral variant presenile dementia presenilin 1 mutation

Journal

Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863

Informations de publication

Date de publication:
2019
Historique:
pubmed: 10 6 2019
medline: 17 9 2020
entrez: 10 6 2019
Statut: ppublish

Résumé

Alzheimer's disease may mimic frontotemporal dementia. We describe a case of presenile dementia who presented with peudo-psychotic symptoms carrying a PSEN1 mutation (P355 S), which was not known to be pathogenic. PET-FDG showed bilateral frontotemporal hypometabolism, but at MRI, multiple microbleeds were detected, suggestive of amyloid angiopathy.

Identifiants

DOI: 10.3233/JAD-190363 PMID: 31177233
pubmed: 31177233
pii: JAD190363
doi: 10.3233/JAD-190363
doi:

Substances chimiques

PSEN1 protein, human 0
Presenilin-1 0

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11-15

Auteurs

Fiammetta Monacelli (F)

Department of Internal Medicine and Medical Specialities, DIMI, Section of Geriatrics, Genoa, Italy.
Ospedale Policlinico San Martino, I.R.C.C.S. Per l'Oncologia, Genoa, Italy.

Lucia Martella (L)

Department of Internal Medicine and Medical Specialities, DIMI, Section of Geriatrics, Genoa, Italy.
Ospedale Policlinico San Martino, I.R.C.C.S. Per l'Oncologia, Genoa, Italy.

Maria Nives Parodi (MN)

Department of Internal Medicine and Medical Specialities, DIMI, Section of Geriatrics, Genoa, Italy.
Ospedale Policlinico San Martino, I.R.C.C.S. Per l'Oncologia, Genoa, Italy.

Patrizio Odetti (P)

Department of Internal Medicine and Medical Specialities, DIMI, Section of Geriatrics, Genoa, Italy.
Ospedale Policlinico San Martino, I.R.C.C.S. Per l'Oncologia, Genoa, Italy.

Francesca Fanelli (F)

Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy.

Massimo Tabaton (M)

Ospedale Policlinico San Martino, I.R.C.C.S. Per l'Oncologia, Genoa, Italy.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Frontal Variant of Alzheimer's Disease: A...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Frontal Variant of Alzheimer's Disease: A...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Frontal Variant of Alzheimer's Disease: A...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Frontal Variant of Alzheimer's Disease: A...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Frontal Variant of Alzheimer's Disease: A...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Frontal Variant of Alzheimer's Disease: A...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Frontal Variant of Alzheimer's Disease: A...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Présénilines › Préséniline-1 › Frontal Variant of Alzheimer's Disease: A...