Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.
Brain asymmetry
Laterality
Mega-analysis
Obsessive-compulsive disorder
Pallidum
Thalamus
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
20
11
2018
revised:
21
03
2019
accepted:
10
04
2019
pubmed:
11
6
2019
medline:
7
1
2021
entrez:
11
6
2019
Statut:
ppublish
Résumé
Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
Sections du résumé
BACKGROUND
Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD.
METHODS
We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status.
RESULTS
In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets.
CONCLUSIONS
The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
Identifiants
pubmed: 31178097
pii: S0006-3223(19)31292-2
doi: 10.1016/j.biopsych.2019.04.022
pmc: PMC7094802
mid: NIHMS1069252
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1022-1034Subventions
Organisme : NIMH NIH HHS
ID : R21 MH101441
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH092397
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH104515
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH082176
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH110865
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085900
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000067
Pays : United States
Organisme : Wellcome-DBT India Alliance
ID : 500236/Z/11/Z
Pays : International
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211155/Z/18/Z
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : K23 MH115206
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH081864
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH093889
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR000069
Pays : United States
Investigateurs
Xiang-Zhen Kong
(XZ)
Premika S W Boedhoe
(PSW)
Yoshinari Abe
(Y)
Pino Alonso
(P)
Stephanie H Ameis
(SH)
Alan Anticevic
(A)
Paul D Arnold
(PD)
Francesca Assogna
(F)
Justin T Baker
(JT)
Nerisa Banaj
(N)
Nuria Bargalló
(N)
Marcelo C Batistuzzo
(MC)
Francesco Benedetti
(F)
Jan C Beucke
(JC)
Irene Bollettini
(I)
Anushree Bose
(A)
Daniel Brandeis
(D)
Silvia Brem
(S)
Brian P Brennan
(BP)
Jan Buitelaar
(J)
Geraldo F Busatto
(GF)
Anna Calvo
(A)
Rosa Calvo
(R)
Yuqi Cheng
(Y)
Kang Ik K Cho
(KIK)
Valentina Ciullo
(V)
Sara Dallaspezia
(S)
Damiaan Denys
(D)
Froukje E de Vries
(FE)
Stella J de Wit
(SJ)
Erin Dickie
(E)
Renate Drechsler
(R)
Benjamin A Ely
(BA)
Madalena Esteves
(M)
Andrea Falini
(A)
Yu Fang
(Y)
Jamie Feusner
(J)
Martijn Figee
(M)
Kate D Fitzgerald
(KD)
Martine Fontaine
(M)
Jean-Paul Fouche
(JP)
Egill A Fridgeirsson
(EA)
Patricia Gruner
(P)
Deniz A Gürsel
(DA)
Geoff Hall
(G)
Sayo Hamatani
(S)
Gregory L Hanna
(GL)
Bjarne Hansen
(B)
Tobias U Hauser
(TU)
Yoshiyuki Hirano
(Y)
Marcelo Q Hoexter
(MQ)
Hao Hu
(H)
Chaim Huyser
(C)
Keisuke Ikari
(K)
Neda Jahanshad
(N)
Anthony James
(A)
Fern Jaspers-Fayer
(F)
Norbert Kathmann
(N)
Christian Kaufmann
(C)
Kathrin Koch
(K)
Masaru Kuno
(M)
Gerd Kvale
(G)
Jun Soo Kwon
(JS)
Luisa Lazaro
(L)
Yanni Liu
(Y)
Christine Lochner
(C)
Ricardo Magalhães
(R)
Paulo Marques
(P)
Rachel Marsh
(R)
Ignacio Martínez-Zalacaín
(I)
Yasutaka Masuda
(Y)
David Mataix-Cols
(D)
Koji Matsumoto
(K)
James T McCracken
(JT)
José M Menchón
(JM)
Euripedes C Miguel
(EC)
Luciano Minuzzi
(L)
Pedro S Moreira
(PS)
Astrid Morer
(A)
Pedro Morgado
(P)
Akiko Nakagawa
(A)
Takashi Nakamae
(T)
Tomohiro Nakao
(T)
Janardhanan C Narayanaswamy
(JC)
Jin Narumoto
(J)
Seiji Nishida
(S)
Erika L Nurmi
(EL)
Joseph O'Neill
(J)
Jose C Pariente
(JC)
Chris Perriello
(C)
John Piacentini
(J)
Fabrizio Piras
(F)
Federica Piras
(F)
Christopher Pittenger
(C)
Sara Poletti
(S)
Y C Janardhan Reddy
(YCJ)
Tim Reess
(T)
Oana Georgiana Rus-Oswald
(OG)
Yuki Sakai
(Y)
Joao R Sato
(JR)
Lianne Schmaal
(L)
Eiji Shimizu
(E)
H Blair Simpson
(HB)
Noam Soreni
(N)
Carles Soriano-Mas
(C)
Nuno Sousa
(N)
Gianfranco Spalletta
(G)
Emily R Stern
(ER)
Michael C Stevens
(MC)
S Evelyn Stewart
(SE)
Philip R Szeszko
(PR)
Jumpei Takahashi
(J)
Jinsong Tang
(J)
Anders Lillevik Thorsen
(AL)
David F Tolin
(DF)
Aki Tsuchiyagaito
(A)
Daan van Rooij
(D)
Guido A van Wingen
(GA)
Ysbrand D van der Werf
(YD)
Dick J Veltman
(DJ)
Daniela Vecchio
(D)
Ganesan Venkatasubramanian
(G)
Susanne Walitza
(S)
Zhen Wang
(Z)
Anri Watanabe
(A)
Jian Xu
(J)
Xiufeng Xu
(X)
Kei Yamada
(K)
Tokiko Yoshida
(T)
Je-Yeon Yun
(JY)
Mojtaba Zarei
(M)
Qing Zhao
(Q)
Cong Zhou
(C)
Paul M Thompson
(PM)
Dan J Stein
(DJ)
Odile A van den Heuvel
(OA)
Clyde Francks
(C)
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Références
Cereb Cortex. 2012 Oct;22(10):2241-62
pubmed: 22047963
Mol Psychiatry. 2017 Jun;22(6):900-909
pubmed: 27137745
Brain Imaging Behav. 2014 Jun;8(2):153-82
pubmed: 24399358
Arch Gen Psychiatry. 2000 Apr;57(4):358-63
pubmed: 10768697
Am J Psychiatry. 2018 May 1;175(5):453-462
pubmed: 29377733
Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5154-E5163
pubmed: 29764998
Am J Psychiatry. 2018 Apr 1;175(4):359-369
pubmed: 29145754
Int J Psychophysiol. 2005 Jul;57(1):69-77
pubmed: 15935263
Biol Psychiatry. 2018 Feb 1;83(3):244-253
pubmed: 29217296
Biol Psychiatry. 1991 May 1;29(9):900-8
pubmed: 2049488
Eur Neuropsychopharmacol. 2016 May;26(5):810-27
pubmed: 26711687
JAMA Psychiatry. 2013 Jul;70(7):709-17
pubmed: 23699935
Am J Psychiatry. 2016 Sep 9;174(1):60-69
pubmed: 27609241
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1208-13
pubmed: 25583500
Neuroimage. 2006 May 1;30(4):1414-32
pubmed: 16413796
Brain. 2012 Mar;135(Pt 3):949-60
pubmed: 22350062
Nat Rev Neurosci. 2013 May;14(5):365-76
pubmed: 23571845
Neuropsychologia. 2016 Dec;93(Pt B):350-364
pubmed: 27020136
Behav Brain Sci. 2003 Apr;26(2):199-208; discussion 208-60
pubmed: 14621511
Psychiatry Res. 1993 Nov;49(2):167-81
pubmed: 8153189
J ECT. 2015 Dec;31(4):271-2
pubmed: 25651393
Psychiatry Res. 2007 Oct 31;153(2):189-93
pubmed: 17629572
Ann N Y Acad Sci. 1977 Sep 30;299:380-96
pubmed: 280215
Psychophysiology. 1993 Jan;30(1):82-9
pubmed: 8416065
Nat Neurosci. 2003 Jul;6(7):750-7
pubmed: 12808459
Br J Psychiatry. 2018 Jul;213(1):430-436
pubmed: 29947313
Schizophr Bull. 1990;16(3):433-43
pubmed: 2287933
Brain Imaging Behav. 2017 Oct;11(5):1497-1514
pubmed: 27738994
Hum Brain Mapp. 2014 Dec;35(12):5717-35
pubmed: 25044828
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1574-9
pubmed: 18582524
Psychophysiology. 2014 Jul;51(7):596-601
pubmed: 24673721
Hum Brain Mapp. 2017 Apr;38(4):2260-2275
pubmed: 28117508
Acta Neuropsychiatr. 2015 Aug;27(4):242-7
pubmed: 25913719
Am J Psychiatry. 1989 Aug;146(8):1001-5
pubmed: 2750970
Cereb Cortex. 2017 Apr 1;27(4):2560-2570
pubmed: 27114178
Mol Psychiatry. 2018 May;23(5):1181-1188
pubmed: 28761083
Neuropsychologia. 2017 Jan 8;94:75-83
pubmed: 27916670
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Science. 2015 Sep 25;349(6255):1489-94
pubmed: 26404826
Mol Psychiatry. 2016 Jun;21(6):806-12
pubmed: 26122586
Biol Psychiatry. 2002 Jul 1;52(1):15-23
pubmed: 12079726
Can J Psychiatry. 2002 Aug;47(6):538-45
pubmed: 12211881
Depress Anxiety. 2010 Jun;27(6):556-72
pubmed: 20336805
Psychiatry Clin Neurosci. 2004 Feb;58(1):16-20
pubmed: 14678451
Nat Rev Neurosci. 2014 Jun;15(6):410-24
pubmed: 24840803
Psychophysiology. 2010 Jul 1;47(4):728-38
pubmed: 20158678
Biol Psychol. 2004 Oct;67(1-2):7-49
pubmed: 15130524
Neuroimage Clin. 2016 Dec 10;13:246-255
pubmed: 28018851
Eur Neuropsychopharmacol. 2005 Aug;15(4):357-76
pubmed: 15961293
Biol Psychol. 2004 Feb;65(3):185-236
pubmed: 14757309
Nat Protoc. 2015 Feb;10(2):293-304
pubmed: 25591011
Behav Brain Res. 2009 Jan 23;196(2):155-67
pubmed: 18955088
Psychiatry Res. 2015 Dec 30;234(3):346-51
pubmed: 26522981
Science. 2013 Jun 7;340(6137):1234-9
pubmed: 23744948
Biol Psychiatry. 1993 Mar 15;33(6):423-30
pubmed: 8490069
Mol Psychiatry. 2010 Jan;15(1):53-63
pubmed: 18725912
Biol Psychiatry. 1984 Nov;19(11):1507-24
pubmed: 6518205
Cereb Cortex. 2005 Jan;15(1):31-9
pubmed: 15238447
Biol Psychiatry. 2018 Nov 1;84(9):644-654
pubmed: 29960671
Clin Psychol Rev. 2013 Dec;33(8):1163-71
pubmed: 24128603