Strain-Release Driven Cycloadditions for Rapid Construction of Functionalized Pyridines and Amino Alcohols.

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
21 06 2019
Historique:
pubmed: 11 6 2019
medline: 11 6 2019
entrez: 11 6 2019
Statut: ppublish

Résumé

This paper describes the development of a new variant of stereoselective strain-release driven reactions (formal homo [3 + 2] dipolar cycloadditions) which utilize housane (1) to construct functionalized amino alcohols and pyridine-substituted cyclopentanes in two to three steps from simple and easily available building blocks (nitrones and pyridine N-oxides respectively).

Identifiants

DOI: 10.1021/acs.orglett.9b01652 PMID: 31180685
pubmed: 31180685
doi: 10.1021/acs.orglett.9b01652
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4763-4766

Auteurs

Sebastian Clementson (S)

Molecular Discovery and Innovation , H. Lundbeck A/S , Ottiliavej 9 , 2500 Valby , Denmark.

Alessio Radaelli (A)

Molecular Discovery and Innovation , H. Lundbeck A/S , Ottiliavej 9 , 2500 Valby , Denmark.
Department of Chemistry , Technical University of Denmark , 207 Kemitorvet , 2900 Kgs. Lyngby , Denmark.

Kasper Fjelbye (K)

Molecular Discovery and Innovation , H. Lundbeck A/S , Ottiliavej 9 , 2500 Valby , Denmark.

David Tanner (D)

Department of Chemistry , Technical University of Denmark , 207 Kemitorvet , 2900 Kgs. Lyngby , Denmark.

Mikkel Jessing (M)

Molecular Discovery and Innovation , H. Lundbeck A/S , Ottiliavej 9 , 2500 Valby , Denmark.

Classifications MeSH