Cyclophillin A deficiency accelerates RML-induced prion disease.
Microglia
Neuroinflamation
PPIA
PrP
Prion protein
Protein misfolding
Scrapie
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
02
04
2019
revised:
14
05
2019
accepted:
05
06
2019
pubmed:
11
6
2019
medline:
25
3
2020
entrez:
11
6
2019
Statut:
ppublish
Résumé
Prion diseases typically involve brain deposition of abnormally folded prion protein, which is associated with activated glia and increased cytokine production. Cyclophilin A (CypA) is a ubiquitous protein with peptidyl prolyl cis-trans isomerase activity, which regulates protein folding, and can be secreted by cells in response to inflammatory stimuli. On the basis of in vitro studies, CypA was proposed to mediate glial activation during prion infection. To investigate the role of CypA in vivo, we inoculated CypA
Identifiants
pubmed: 31181281
pii: S0969-9961(19)30153-6
doi: 10.1016/j.nbd.2019.104498
pii:
doi:
Substances chimiques
Peptidylprolyl Isomerase
EC 5.2.1.8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104498Subventions
Organisme : Telethon
ID : TCR08002
Pays : Italy
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.