A Novel Animal Model of Emphysema Induced by Anti-Elastin Autoimmunity.
Adaptive Immunity
/ immunology
Animals
Autoimmunity
/ immunology
Cell Line
Disease Models, Animal
Elastin
/ immunology
Female
HEK293 Cells
Humans
Immune Tolerance
/ immunology
Immunity, Innate
/ immunology
Inflammation
/ immunology
Lung
/ immunology
Mice
Mice, Inbred C57BL
Pulmonary Disease, Chronic Obstructive
/ immunology
Pulmonary Emphysema
/ immunology
Smoking
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
received:
05
02
2019
accepted:
13
05
2019
pubmed:
12
6
2019
medline:
15
2
2020
entrez:
12
6
2019
Statut:
ppublish
Résumé
Loss of immune tolerance to self-antigens can promote chronic inflammation and disrupt the normal function of multiple organs, including the lungs. Degradation of elastin, a highly insoluble protein and a significant component of the lung structural matrix, generates proinflammatory molecules. Elastin fragments (EFs) have been detected in the serum of smokers with emphysema, and elastin-specific T cells have also been detected in the peripheral blood of smokers with emphysema. However, an animal model that could recapitulate T cell-specific autoimmune responses by initiating and sustaining inflammation in the lungs is lacking. In this study, we report an animal model of autoimmune emphysema mediated by the loss of tolerance to elastin. Mice immunized with a combination of human EFs plus rat EFs but not mouse EFs showed increased infiltration of innate and adaptive immune cells to the lungs and developed emphysema. We cloned and expanded mouse elastin-specific CD4
Identifiants
pubmed: 31182478
pii: jimmunol.1900113
doi: 10.4049/jimmunol.1900113
pmc: PMC6688643
mid: NIHMS1529580
doi:
Substances chimiques
Elastin
9007-58-3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
349-359Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL140398
Pays : United States
Organisme : CSRD VA
ID : I01 CX000104
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029442
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125301
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI036211
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI135803
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR024574
Pays : United States
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
Références
Nat Protoc. 2012 Dec;7(12):2180-92
pubmed: 23196974
Am J Respir Crit Care Med. 2006 Apr 1;173(7):751-8
pubmed: 16399994
Elife. 2015 Oct 05;4:e09623
pubmed: 26437452
J Autoimmun. 2018 Dec;95:100-123
pubmed: 30509385
Immunity. 2015 Jun 16;42(6):1100-15
pubmed: 26084025
Proc Am Thorac Soc. 2006 Aug;3(6):486
pubmed: 16921120
Am J Respir Crit Care Med. 1999 Jan;159(1):158-64
pubmed: 9872834
J Vis Exp. 2016 Jul 11;(113):
pubmed: 27500835
BMC Genomics. 2004 May 18;5(1):31
pubmed: 15149554
Annu Rev Immunol. 2002;20:101-23
pubmed: 11861599
PLoS Med. 2004 Oct;1(1):e8
pubmed: 15526056
Expert Rev Respir Med. 2010 Dec;4(6):723-34
pubmed: 21128748
Chest. 2011 Oct;140(4):946-953
pubmed: 21415130
Am Rev Respir Dis. 1983 Feb;127(2):S28-30
pubmed: 6830025
J Immunol. 2008 Dec 1;181(11):8036-43
pubmed: 19017996
Sci Transl Med. 2009 Oct 28;1(4):4ra10
pubmed: 20368170
Hum Pathol. 1989 Jul;20(7):652-9
pubmed: 2661409
Am J Pathol. 2003 Dec;163(6):2329-35
pubmed: 14633606
Am J Pathol. 1996 Oct;149(4):1405-15
pubmed: 8863687
Arthritis Care Res (Hoboken). 2019 May;71(5):602-610
pubmed: 29047218
J Clin Invest. 1998 Dec 1;102(11):1900-10
pubmed: 9835614
Respir Res. 2005 Dec 16;6:147
pubmed: 16359546
Rheumatology (Oxford). 2016 Jul;55(7):1301-7
pubmed: 27048628
Nat Immunol. 2014 Sep;15(9):815-23
pubmed: 25137456
Am J Respir Crit Care Med. 2015 Nov 15;192(10):1171-8
pubmed: 26241705
Nature. 2003 Mar 13;422(6928):169-73
pubmed: 12634787
J Immunol. 2013 Feb 1;190(3):1331-40
pubmed: 23264660
Expert Rev Clin Immunol. 2012 Mar;8(3):285-92
pubmed: 22390492
J Exp Med. 1993 Oct 1;178(4):1435-40
pubmed: 8376946
J Exp Med. 1982 Aug 1;156(2):550-66
pubmed: 6808075
J Clin Invest. 1995 Jul;96(1):318-26
pubmed: 7615801
Nat Med. 2007 May;13(5):567-9
pubmed: 17450149
J Immunol. 2011 Apr 1;186(7):4388-95
pubmed: 21357259
Chest. 1999 Jul;116(1):40-6
pubmed: 10424501
Lupus. 2006;15(11):737-45
pubmed: 17153844
Am J Respir Crit Care Med. 2005 Sep 1;172(5):590-6
pubmed: 15937291
Front Immunol. 2013 Dec 27;4:493
pubmed: 24416033
Arthritis Rheum. 2012 Mar;64(3):678-87
pubmed: 21953132
Atherosclerosis. 1987 May;65(1-2):13-21
pubmed: 3649236
Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1498-505
pubmed: 9603129
Circulation. 2018 Sep 11;138(11):1130-1143
pubmed: 29588316
J Immunol. 2014 Jul 15;193(2):571-9
pubmed: 24943217
Front Physiol. 2013 May 15;4:91
pubmed: 23720629
J Clin Invest. 2002 Sep;110(5):625-32
pubmed: 12208863
J Clin Invest. 2014 Mar;124(3):1371-81
pubmed: 24569375
Nat Clin Pract Rheumatol. 2007 Dec;3(12):707-15
pubmed: 18037930
J Immunol Methods. 2016 Dec;439:29-36
pubmed: 27589924
Am J Respir Crit Care Med. 2004 Nov 1;170(9):974-80
pubmed: 15282203
J Clin Invest. 1991 May;87(5):1828-34
pubmed: 2022748
Front Immunol. 2012 Aug 27;3:267
pubmed: 22969766
Int Immunopharmacol. 2013 Jan;15(1):58-66
pubmed: 23127823
Nat Immunol. 2001 Sep;2(9):781-4
pubmed: 11526385
Anal Biochem. 1976 Aug;74(2):441-7
pubmed: 822746
Matrix Biol. 2015 May-Jul;44-46:167-74
pubmed: 25686691
Am J Respir Crit Care Med. 1998 Oct;158(4):1277-85
pubmed: 9769292
Thorax. 2006 Nov;61(11):935-9
pubmed: 17071833
Science. 1997 Sep 26;277(5334):2002-4
pubmed: 9302297
J Autoimmun. 2010 May;34(3):J258-65
pubmed: 20042314
Curr Opin Immunol. 2019 Aug;59:15-24
pubmed: 30928800
J Immunol. 2003 Jul 1;171(1):462-8
pubmed: 12817031
Lancet. 2006 Apr 15;367(9518):1216-9
pubmed: 16631861
J Histochem Cytochem. 1973 Mar;21(3):199-208
pubmed: 4121415
Nat Immunol. 2009 May;10(5):496-503
pubmed: 19329997
Respir Res. 2009 Nov 12;10:108
pubmed: 19909533
Sci Transl Med. 2012 Jan 18;4(117):117ra9
pubmed: 22261033
Bio Protoc. 2016 Jun 5;6(11):
pubmed: 27335895
J Clin Invest. 2011 Jan;121(1):288-95
pubmed: 21135507