Pharmacokinetic/Pharmacodynamic Evaluation of Solithromycin against Streptococcus pneumoniae Using Data from a Neutropenic Murine Lung Infection Model.
Streptococcus pneumoniae
fluoroketolide
murine lung infection model
pharmacokinetics/pharmacodynamics
solithromycin
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
31
12
2018
accepted:
09
05
2019
pubmed:
12
6
2019
medline:
9
6
2020
entrez:
12
6
2019
Statut:
epublish
Résumé
Solithromycin (CEM-101) is a novel fluoroketolide antimicrobial agent with activity against typical and atypical pathogens associated with community-acquired bacterial pneumonia. Using a neutropenic murine lung infection model, the objectives of this study were to identify the pharmacokinetic/pharmacodynamic (PK/PD) index most closely associated with efficacy and the magnitude of such indices associated with solithromycin efficacy against
Identifiants
pubmed: 31182534
pii: AAC.02606-18
doi: 10.1128/AAC.02606-18
pmc: PMC6658793
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Macrolides
0
Triazoles
0
solithromycin
9U1ETH79CK
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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