The Impact of
Gonadotropins
Male fertility agents
Semen analysis
Testosterone
Echium
Journal
Iranian journal of medical sciences
ISSN: 0253-0716
Titre abrégé: Iran J Med Sci
Pays: Iran
ID NLM: 8104374
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
entrez:
12
6
2019
pubmed:
12
6
2019
medline:
12
6
2019
Statut:
ppublish
Résumé
Iranian borage, In this experimental study, 30 adult male Mus musculus mice (30-35 g) were equally divided into three groups. The control group received distilled water (DW) for five weeks and the other two groups, BD1/2 and BD1/4, received borage distillate of 1/2 dilution (150±2.5 ml/kg/day) and 1/4 dilution (75±1.25 ml/kg/day), respectively, The administration of BD1/2 significantly increased serum FSH (P=0.004), LH (P=0.025), testosterone (P=0.014), the percentage of motile (P=0.011); slow progressive (P=0.001), coiled tail (P<0.001) sperms, and the number of Leydig cells (P=0.008) compared to the control group. Treatment with BD1/4 significantly increased sperm count (P=0.044) and motile sperms percentage (P=0.040) compared to the control group too. The administration of BD revealed no significant effects on toxicity parameters and AR gene expression. The findings of the present study showed that the consumption of borage distillate, as a safe herbal remedy, improves hormonal and sperm parameters in male mice.
Sections du résumé
BACKGROUND
BACKGROUND
Iranian borage,
METHODS
METHODS
In this experimental study, 30 adult male Mus musculus mice (30-35 g) were equally divided into three groups. The control group received distilled water (DW) for five weeks and the other two groups, BD1/2 and BD1/4, received borage distillate of 1/2 dilution (150±2.5 ml/kg/day) and 1/4 dilution (75±1.25 ml/kg/day), respectively,
RESULTS
RESULTS
The administration of BD1/2 significantly increased serum FSH (P=0.004), LH (P=0.025), testosterone (P=0.014), the percentage of motile (P=0.011); slow progressive (P=0.001), coiled tail (P<0.001) sperms, and the number of Leydig cells (P=0.008) compared to the control group. Treatment with BD1/4 significantly increased sperm count (P=0.044) and motile sperms percentage (P=0.040) compared to the control group too. The administration of BD revealed no significant effects on toxicity parameters and AR gene expression.
CONCLUSION
CONCLUSIONS
The findings of the present study showed that the consumption of borage distillate, as a safe herbal remedy, improves hormonal and sperm parameters in male mice.
Types de publication
Journal Article
Langues
eng
Pagination
227-235Références
Nat Rev Genet. 2002 Oct;3(10):790-801
pubmed: 12360237
Evid Based Complement Alternat Med. 2006 Dec;3(4):469-73
pubmed: 17173110
Pak J Biol Sci. 2007 Jan 1;10(1):90-5
pubmed: 19069991
Nat Rev Urol. 2010 Mar;7(3):153-61
pubmed: 20157305
Exp Toxicol Pathol. 2011 Nov;63(7-8):627-33
pubmed: 20627677
Korean J Urol. 2012 Oct;53(10):705-10
pubmed: 23136631
Pharmacol Rep. 2012;64(6):1537-46
pubmed: 23406764
Int J Mol Sci. 2013 Jun 19;14(6):12780-805
pubmed: 23783276
Clin Exp Reprod Med. 2013 Sep;40(3):115-21
pubmed: 24179868
Asian Pac J Trop Med. 2014 Sep;7S1:S22-8
pubmed: 25312125
Reprod Biol Endocrinol. 2015 Apr 26;13:37
pubmed: 25928197
Malays J Med Sci. 2015 Mar-Apr;22(2):25-32
pubmed: 26023292
Nat Rev Urol. 2015 Jul;12(7):373-82
pubmed: 26057063
Spermatogenesis. 2015 Jan 26;4(2):e996025
pubmed: 26413400
Cell Death Dis. 2016 Mar 24;7:e2152
pubmed: 27010853
J Complement Integr Med. 2016 Jun 1;13(2):123-7
pubmed: 27023323
Nat Rev Urol. 2016 Jun;13(6):309-23
pubmed: 27091665
Int J Reprod Biomed (Yazd). 2016 Feb;14(2):95-102
pubmed: 27200423
Reprod Fertil Dev. 2017 Sep;29(10):1910-1920
pubmed: 27876113
Iran J Med Sci. 2018 Mar;43(2):174-183
pubmed: 29749986
Mikroskopie. 1970 Jun;26(1):57-60
pubmed: 5530651
Am J Anat. 1980 Dec;159(4):412-46
pubmed: 7013463