Dynamical modelling of secondary metabolism and metabolic switches in
Streptomyces
dynamical landscape
metabolic modelling
metabolic switch
secondary metabolism
systems biology
Journal
Royal Society open science
ISSN: 2054-5703
Titre abrégé: R Soc Open Sci
Pays: England
ID NLM: 101647528
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
13
03
2019
accepted:
18
03
2019
entrez:
12
6
2019
pubmed:
12
6
2019
medline:
12
6
2019
Statut:
epublish
Résumé
The production of secondary metabolites, while important for bioengineering purposes, presents a paradox in itself. Though widely existing in plants and bacteria, they have no definite physiological roles. Yet in both native habitats and laboratories, their production appears robust and follows apparent metabolic switches. We show in this work that the enzyme-catalysed process may improve the metabolic stability of the cells. The latter can be responsible for the overall metabolic behaviours such as dynamic metabolic landscape, metabolic switches and robustness, which can in turn affect the genetic formation of the organism in question. Mangrove-derived
Identifiants
pubmed: 31183155
doi: 10.1098/rsos.190418
pii: rsos190418
pmc: PMC6502367
doi:
Banques de données
figshare
['10.6084/m9.figshare.c.4452389']
Types de publication
Journal Article
Langues
eng
Pagination
190418Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
We declare we have no competing interests.
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