Comparison of heparinized saline and 0.9% sodium chloride for maintaining central venous catheter patency in healthy dogs.
Central catheter
Flush
Heparin
Phlebitis
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
02
2019
accepted:
06
05
2019
entrez:
12
6
2019
pubmed:
12
6
2019
medline:
12
6
2019
Statut:
epublish
Résumé
The purpose of this study was to determine whether heparinized saline (HS) would be more effective in maintaining the patency of central venous catheters (CVCs) in dogs compared to 0.9% sodium chloride. This was a prospective randomized blinded study conducted at a University Veterinary Teaching Hospital. A total of 24 healthy purpose-bred dogs were randomized into two groups: a treatment and a control group. A CVC was placed in the jugular vein of each dog. Each dog in the treatment group had their CVC flushed with 10 IU/mL HS, while dogs in the control group had their CVC flushed with 0.9% sodium chloride every 6 h for 72 h. Immediately prior to flushing, each catheter was evaluated for patency by aspiration of blood. The catheter site was also evaluated for phlebitis, and a rectal temperature was obtained in each dog every 6 h. Prothrombin (PT) and activated partial thromboplastin (aPTT) times were evaluated prior to the administration of any flush solution. Results were then compared to values obtained 72 h later. All CVCs in both groups were patent after 72 h, which was demonstrated by aspiration of blood and ease of flushing the catheter. Two CVCs in the 0.9% sodium chloride group had a negative aspiration at hour 12 and 36, respectively. One CVC in the HS group had a negative aspiration at hour 18. Signs of phlebitis occurred in three dog: two in the 0.9% sodium chloride group and one in the HS group. No dog was hyperthermic (>103 °F). Two catheters were inadvertently removed by dogs in the HS group during the study. There were no significant differences in catheter patency, incidence of phlebitis, or incidence of negative aspirations between both groups. aPTT and PT values remained within the normal reference range for all dogs in both groups. Ultimately, 0.9% sodium chloride was as effective as 10 IU/mL HS in maintaining the patency of CVCs for up to 72 h in healthy dogs. Further evaluation in clinical patients is warranted.
Sections du résumé
BACKGROUND
BACKGROUND
The purpose of this study was to determine whether heparinized saline (HS) would be more effective in maintaining the patency of central venous catheters (CVCs) in dogs compared to 0.9% sodium chloride. This was a prospective randomized blinded study conducted at a University Veterinary Teaching Hospital.
METHODS
METHODS
A total of 24 healthy purpose-bred dogs were randomized into two groups: a treatment and a control group. A CVC was placed in the jugular vein of each dog. Each dog in the treatment group had their CVC flushed with 10 IU/mL HS, while dogs in the control group had their CVC flushed with 0.9% sodium chloride every 6 h for 72 h. Immediately prior to flushing, each catheter was evaluated for patency by aspiration of blood. The catheter site was also evaluated for phlebitis, and a rectal temperature was obtained in each dog every 6 h. Prothrombin (PT) and activated partial thromboplastin (aPTT) times were evaluated prior to the administration of any flush solution. Results were then compared to values obtained 72 h later.
RESULTS
RESULTS
All CVCs in both groups were patent after 72 h, which was demonstrated by aspiration of blood and ease of flushing the catheter. Two CVCs in the 0.9% sodium chloride group had a negative aspiration at hour 12 and 36, respectively. One CVC in the HS group had a negative aspiration at hour 18. Signs of phlebitis occurred in three dog: two in the 0.9% sodium chloride group and one in the HS group. No dog was hyperthermic (>103 °F). Two catheters were inadvertently removed by dogs in the HS group during the study. There were no significant differences in catheter patency, incidence of phlebitis, or incidence of negative aspirations between both groups. aPTT and PT values remained within the normal reference range for all dogs in both groups. Ultimately, 0.9% sodium chloride was as effective as 10 IU/mL HS in maintaining the patency of CVCs for up to 72 h in healthy dogs. Further evaluation in clinical patients is warranted.
Identifiants
pubmed: 31183263
doi: 10.7717/peerj.7072
pii: 7072
pmc: PMC6546076
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e7072Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Hosp Pharm. 1990 Feb;25(2):115-8
pubmed: 10103699
Clin Nutr. 2000 Aug;19(4):237-43
pubmed: 10952794
J Vasc Interv Radiol. 2003 May;14(5):527-34
pubmed: 12761305
Oncologist. 2004;9(2):207-16
pubmed: 15047925
Aust Vet J. 2003 Mar;81(3):136-9
pubmed: 15080425
Prog Cardiovasc Nurs. 2005 Fall;20(4):143-7
pubmed: 16276136
Postgrad Med J. 2007 Sep;83(983):575-82
pubmed: 17823223
Am J Med. 2007 Oct;120(10):901.e1-13
pubmed: 17904462
Nurs Res. 1991 Nov-Dec;40(6):324-30
pubmed: 1835537
Aust Vet J. 2010 Jun;88(6):215-21
pubmed: 20553569
J Adv Nurs. 2009 Oct;65(10):2007-21
pubmed: 20568318
Cochrane Database Syst Rev. 2011 Apr 13;(4):CD006468
pubmed: 21491394
Crit Care Med. 2012 Jun;40(6):1820-6
pubmed: 22488006
J Thromb Haemost. 2013 Jan;11(1):56-70
pubmed: 23217107
Clin Radiol. 2013 May;68(5):529-44
pubmed: 23415017
J Vet Emerg Crit Care (San Antonio). 2013 Sep-Oct;23(5):517-22
pubmed: 24016312
BMJ. 2013 Nov 11;347:f6570
pubmed: 24217269
Blood Coagul Fibrinolysis. 2014 Mar;25(2):97-106
pubmed: 24477225
Acta Anaesthesiol Scand. 2014 May;58(5):508-24
pubmed: 24593804
J Thromb Haemost. 2014 Jul;12(7):1096-109
pubmed: 24801495
J Vasc Access. 2014 Jul-Aug;15(4):241-8
pubmed: 24811598
Cochrane Database Syst Rev. 2014 Oct 08;(10):CD008462
pubmed: 25300172
Anesth Pain Med. 2015 Mar 30;5(2):e22595
pubmed: 25866710
Nurs Res Pract. 2015;2015:985686
pubmed: 26075094
N Engl J Med. 2015 Sep 24;373(13):1220-9
pubmed: 26398070
Anesth Pain Med. 2015 Aug 22;5(4):e28056
pubmed: 26478866
Cochrane Database Syst Rev. 2015 Nov 23;(11):CD010996
pubmed: 26590504
Int J Nurs Stud. 2016 Jul;59:51-9
pubmed: 27222450
Crit Care. 2017 Jan 8;21(1):5
pubmed: 28063456
Blood. 2017 Oct 5;130(14):1679-1682
pubmed: 28830891
Front Pharmacol. 2017 Sep 19;8:644
pubmed: 28974929
Clin J Oncol Nurs. 2018 Apr 1;22(2):199-202
pubmed: 29547607
J Vet Emerg Crit Care (San Antonio). 2018 May;28(3):232-243
pubmed: 29687942
Cochrane Database Syst Rev. 2018 Jul 30;7:CD008462
pubmed: 30058070
Am J Med Sci. 1988 Jul;296(1):71-3
pubmed: 3407682
JPEN J Parenter Enteral Nutr. 1995 Jan-Feb;19(1):75-9
pubmed: 7658605
Am J Med. 1993 Oct;95(4):419-23
pubmed: 8213875
J Am Anim Hosp Assoc. 1995 Sep-Oct;31(5):379-84
pubmed: 8542353
J R Soc Med. 1997 Jun;90(6):319-21
pubmed: 9227379
J Emerg Nurs. 1997 Aug;23(4):306-9
pubmed: 9379571
Chest. 1998 Jul;114(1):207-13
pubmed: 9674471