PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.

Animals Diabetes Mellitus, Type 2 / genetics Diet, High-Fat / adverse effects Disulfides / metabolism Endoplasmic Reticulum / metabolism Glucose Intolerance / genetics Insulin / metabolism Insulin-Secreting Cells / metabolism Mice, Knockout Mice, Transgenic Mitochondrial Swelling Obesity / etiology Oxidative Stress Procollagen-Proline Dioxygenase / genetics Proinsulin / metabolism Protein Disulfide-Isomerases / genetics
PDIA1 beta cell function cell biology disulfide bond formation glucose homeostasis mouse proinsulin maturation type 2 diabetes

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
11 06 2019
Historique:
received: 19 12 2018
accepted: 15 05 2019
entrez: 12 6 2019
pubmed: 12 6 2019
medline: 3 3 2020
Statut: epublish

Résumé

Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to prevent Type two diabetes. In ß cells, protein disulfide isomerase A1 (PDIA1/

Identifiants

DOI: 10.7554/eLife.44528 PMID: 31184304 PMC: PMC6559792
pubmed: 31184304
doi: 10.7554/eLife.44528
pii: 44528
pmc: PMC6559792
doi:
pii:

Substances chimiques

Disulfides 0
Insulin 0
Proinsulin 9035-68-1
Procollagen-Proline Dioxygenase EC 1.14.11.2
P4hb protein, mouse EC 5.3.4.1
Protein Disulfide-Isomerases EC 5.3.4.1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : R01DK103185
Pays : United States
Organisme : NIH HHS
ID : P30 CA030199
Pays : United States
Organisme : NIDDK NIH HHS
ID : R24 DK110973
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK098085
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113171
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIH HHS
ID : R01DK113171
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA030199
Pays : United States
Organisme : NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103185
Pays : United States
Organisme : NIH HHS
ID : R24DK110973
Pays : United States

Informations de copyright

© 2019, Jang et al.

Déclaration de conflit d'intérêts

IJ, AP, JP, JY, JL, AC, ZC, DS, ML, PI, PA, RK No competing interests declared

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Auteurs

Insook Jang (I)

Degenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.
ORCID: 0000-0001-7567-3849

Anita Pottekat (A)

Degenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.

Juthakorn Poothong (J)

Degenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.

Jing Yong (J)

Degenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.
ORCID: 0000-0002-4970-408X

Jacqueline Lagunas-Acosta (J)

Degenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.

Adriana Charbono (A)

Degenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.

Zhouji Chen (Z)

Degenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.

Donalyn L Scheuner (DL)

DLS Consulting, Greenfield, United States.

Ming Liu (M)

Division of Metabolism Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, United States.

Pamela Itkin-Ansari (P)

Department of Pediatrics, University of California, San Diego, San Diego, United States.

Peter Arvan (P)

Division of Metabolism Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, United States.
ORCID: 0000-0002-4007-8799

Randal J Kaufman (RJ)

Degenerative Diseases Program, SBP Medical Discovery Institute, La Jolla, United States.
ORCID: 0000-0003-4277-316X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfures › Disulfures › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperglycémie › Intolérance au glucose › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Gonflement mitochondrial › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Prolyl hydroxylases › Procollagen-Proline Dioxygenase › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Précurseurs de protéines › Proinsuline › PDIA1/P4HB is required for efficient...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Intramolecular oxidoreductases › Sulfur-sulfur bond isomerase › Protein Disulfide-Isomerases › PDIA1/P4HB is required for efficient...