Comparison of the efficacy of indocyanine green-mediated photodynamic therapy and nystatin therapy in treatment of denture stomatitis.
Aged
Antifungal Agents
/ therapeutic use
Candidiasis, Oral
/ drug therapy
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Indocyanine Green
/ therapeutic use
Lasers, Semiconductor
Male
Middle Aged
Nystatin
/ administration & dosage
Photochemotherapy
/ methods
Photosensitizing Agents
/ therapeutic use
Stomatitis, Denture
/ drug therapy
Antifungal agent
Candida
Denture stomatitis
Indocyanine green
Photodynamic therapy
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
07
04
2019
revised:
17
05
2019
accepted:
07
06
2019
pubmed:
12
6
2019
medline:
11
2
2020
entrez:
12
6
2019
Statut:
ppublish
Résumé
Candida species have an influence in the pathogenesis of denture stomatitis. The current study aimed to investigate the efficacy of indocyanine green (ICG)-mediated photodynamic therapy (PDT) in combination with nystatin mouthwash (PDT + nystatin) for the treatment of denture stomatitis in comparison with routine antifungal therapy with nystatin alone. In this double-blind randomized clinical trial, 66 patients were randomly assigned into PDT + nystatin (n = 33) and nystatin (n = 33) groups, both groups were treated 3-times a day (15 days) with nystatin mouthwash, and PDT was performed twice once a week for the PDT + nystatin group. Briefly, ICG was applied on the palatal lesion and laser irradiation was performed using a diode laser (810 nm, 56 J/cm Patient treatment with nystatin or PDT + nystatin reduced the lesions extension. Candida species were isolated from all patients and the number of Candida CFU in both groups showed a significant reduction at each post-treatment visit; however, the mean reduction achieved in the PDT + nystatin group was significantly higher than nystatin alone. ICG-mediated PDT in combination with nystatin mouthwash can improve the clinical feature of denture stomatitis with no adverse effects; therefore, it could be used as an alternative to the currently available antifungal therapy using nystatin alone.
Sections du résumé
BACKGROUND
BACKGROUND
Candida species have an influence in the pathogenesis of denture stomatitis. The current study aimed to investigate the efficacy of indocyanine green (ICG)-mediated photodynamic therapy (PDT) in combination with nystatin mouthwash (PDT + nystatin) for the treatment of denture stomatitis in comparison with routine antifungal therapy with nystatin alone.
METHODS
METHODS
In this double-blind randomized clinical trial, 66 patients were randomly assigned into PDT + nystatin (n = 33) and nystatin (n = 33) groups, both groups were treated 3-times a day (15 days) with nystatin mouthwash, and PDT was performed twice once a week for the PDT + nystatin group. Briefly, ICG was applied on the palatal lesion and laser irradiation was performed using a diode laser (810 nm, 56 J/cm
RESULTS
RESULTS
Patient treatment with nystatin or PDT + nystatin reduced the lesions extension. Candida species were isolated from all patients and the number of Candida CFU in both groups showed a significant reduction at each post-treatment visit; however, the mean reduction achieved in the PDT + nystatin group was significantly higher than nystatin alone.
CONCLUSIONS
CONCLUSIONS
ICG-mediated PDT in combination with nystatin mouthwash can improve the clinical feature of denture stomatitis with no adverse effects; therefore, it could be used as an alternative to the currently available antifungal therapy using nystatin alone.
Identifiants
pubmed: 31185323
pii: S1572-1000(19)30166-8
doi: 10.1016/j.pdpdt.2019.06.005
pii:
doi:
Substances chimiques
Antifungal Agents
0
Photosensitizing Agents
0
Nystatin
1400-61-9
Indocyanine Green
IX6J1063HV
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-197Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.