Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma.
T lymphocytes
alarmin
cytokine
immunosurveillance
inflammation
monoclonal gammopathy of undetermined significance
multiple myeloma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Jun 2019
10 Jun 2019
Historique:
received:
16
04
2019
revised:
29
05
2019
accepted:
08
06
2019
entrez:
13
6
2019
pubmed:
13
6
2019
medline:
20
11
2019
Statut:
epublish
Résumé
Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs.
Identifiants
pubmed: 31185596
pii: ijms20112822
doi: 10.3390/ijms20112822
pmc: PMC6600674
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Cancer Res. 1999 Aug 15;59(16):4035-41
pubmed: 10463604
Hematol Oncol Clin North Am. 1999 Dec;13(6):1181-202
pubmed: 10626144
Blood. 2000 Jul 15;96(2):384-92
pubmed: 10887096
Clin Immunol. 2001 Mar;98(3):301-7
pubmed: 11237552
Cancer. 2001 Mar 1;91(5):900-8
pubmed: 11251941
Cancer. 2001 Apr 1;91(7):1219-30
pubmed: 11283920
Blood. 2001 Jul 1;98(1):210-6
pubmed: 11418482
Blood. 2001 Jul 15;98(2):428-35
pubmed: 11435313
Intern Med J. 2001 Jul;31(5):272-8
pubmed: 11512598
Clin Exp Immunol. 2001 Aug;125(2):190-7
pubmed: 11529908
Blood. 2001 Nov 1;98(9):2817-27
pubmed: 11675356
Blood. 2002 Mar 1;99(5):1745-57
pubmed: 11861292
Br J Haematol. 2002 May;117(2):387-9
pubmed: 11972522
Nat Rev Cancer. 2002 Mar;2(3):175-87
pubmed: 11990854
Leukemia. 2002 Jun;16(6):1182-8
pubmed: 12040451
Blood. 2002 Aug 15;100(4):1417-24
pubmed: 12149226
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13009-13
pubmed: 12235374
Mol Cancer Ther. 2002 May;1(7):539-44
pubmed: 12479272
Hematol Oncol. 2003 Mar;21(1):33-42
pubmed: 12605421
Leukemia. 2003 Apr;17(4):764-74
pubmed: 12682635
Blood. 2003 Aug 15;102(4):1435-42
pubmed: 12714512
Leukemia. 2003 Jun;17(6):1175-82
pubmed: 12764386
J Exp Med. 2003 Jun 16;197(12):1667-76
pubmed: 12796469
Acta Haematol. 1992;88(2-3):129-35
pubmed: 1281599
Adv Immunol. 1992;52:125-262
pubmed: 1442306
J Exp Med. 2003 Dec 1;198(11):1753-7
pubmed: 14638846
J Exp Med. 2003 Dec 1;198(11):1623-6
pubmed: 14638849
Curr Top Microbiol Immunol. 1992;182:237-44
pubmed: 1490360
Blood. 2005 Mar 1;105(5):2132-4
pubmed: 15561890
Leuk Res. 2005 Feb;29(2):135-40
pubmed: 15607360
Hepatology. 2005 Mar;41(3):609-16
pubmed: 15726652
Blood. 2006 Jan 1;107(1):301-4
pubmed: 16150935
Eur J Cancer. 2005 Nov;41(17):2645-54
pubmed: 16239109
Cancer. 2006 Mar 15;106(6):1296-305
pubmed: 16475149
Histopathology. 2006 May;48(6):692-701
pubmed: 16681685
Oncol Rep. 2006 Aug;16(2):329-34
pubmed: 16820911
Blood. 1990 Feb 1;75(3):589-95
pubmed: 1688719
Blood. 1990 Jul 15;76(2):377-82
pubmed: 1695113
Science. 2006 Sep 29;313(5795):1960-4
pubmed: 17008531
Clin Exp Immunol. 1991 Mar;83(3):418-22
pubmed: 1706237
Leukemia. 2007 Jan;21(1):158-63
pubmed: 17096013
Haematologica. 2007 Jan;92(1):110-4
pubmed: 17229643
Leukemia. 2007 May;21(5):1079-88
pubmed: 17344918
J Exp Med. 2007 Apr 16;204(4):831-40
pubmed: 17389240
Growth Factors. 1991;5(4):327-38
pubmed: 1777241
Leuk Lymphoma. 2007 Oct;48(10):2032-41
pubmed: 17917971
Haematologica. 2008 Mar;93(3):423-30
pubmed: 18287134
Arch Immunol Ther Exp (Warsz). 2008 May-Jun;56(3):207-21
pubmed: 18512025
Blood. 2008 Oct 1;112(7):2878-85
pubmed: 18669891
Pathol Oncol Res. 2009 Mar;15(1):65-72
pubmed: 18752046
Cancer Res. 2008 Oct 15;68(20):8456-64
pubmed: 18922919
Blood. 2009 Feb 26;113(9):1992-2002
pubmed: 19060246
Blood. 1991 Oct 15;78(8):2070-4
pubmed: 1912585
Blood. 2009 May 28;113(22):5412-7
pubmed: 19179464
Blood. 2009 May 28;113(22):5418-22
pubmed: 19234139
J Exp Clin Cancer Res. 2009 Mar 10;28:35
pubmed: 19284554
Exp Cell Res. 2009 Jul 1;315(11):1904-13
pubmed: 19328780
Leukemia. 2009 Aug;23(8):1515-27
pubmed: 19357701
Curr Pharm Des. 2009;15(16):1879-92
pubmed: 19519430
Leukemia. 2009 Nov;23(11):2177-81
pubmed: 19587705
Haematologica. 2009 Dec;94(12):1708-13
pubmed: 19996118
Blood. 2010 Feb 11;115(6):1185-93
pubmed: 20008301
Ann Hematol. 1991 Feb-Mar;62(2-3):54-8
pubmed: 2031968
Br J Haematol. 1991 May;78(1):60-5
pubmed: 2043483
Clin Exp Immunol. 1991 Jun;84(3):429-34
pubmed: 2044221
Int J Dermatol. 2010 Apr;49(4):435-7
pubmed: 20465701
DNA Repair (Amst). 2010 Dec 10;9(12):1229-40
pubmed: 21056014
Eur J Haematol. 2011 Feb;86(2):93-110
pubmed: 21114539
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Clin Dev Immunol. 2011;2011:734036
pubmed: 21904560
Nat Rev Cancer. 2012 Mar 15;12(4):298-306
pubmed: 22419253
Am J Hematol. 2013 Feb;88(2):89-92
pubmed: 23169485
Br J Haematol. 2013 Mar;160(5):709-10
pubmed: 23205532
J Transl Med. 2012 Dec 11;10:247
pubmed: 23232072
Front Biosci (Landmark Ed). 2013 Jan 01;18:324-31
pubmed: 23276925
Trends Mol Med. 2013 Feb;19(2):108-16
pubmed: 23306374
Allergy. 2013;68(5):562-8
pubmed: 23480774
Front Genet. 2013 Apr 01;4:45
pubmed: 23554604
Front Genet. 2013 Jun 11;4:106
pubmed: 23781231
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Oct;21(5):1187-9
pubmed: 24156431
J Biol Chem. 1986 Mar 15;261(8):3648-53
pubmed: 2419335
Acta Haematol. 2014;131(3):165-6
pubmed: 24217710
Hematology Am Soc Hematol Educ Program. 2013;2013:478-87
pubmed: 24319222
Klin Onkol. 2014;27(1):18-23
pubmed: 24635433
Tissue Antigens. 2014 Apr;83(4):237-46
pubmed: 24641502
Blood. 1989 Sep;74(4):1266-73
pubmed: 2475182
J Postgrad Med. 2014 Apr-Jun;60(2):141-4
pubmed: 24823512
Inflammation. 2015 Apr;38(2):705-9
pubmed: 25034833
Semin Hematol. 1989 Jul;26(3):176-200
pubmed: 2506645
Cancers (Basel). 2014 Aug 12;6(3):1631-69
pubmed: 25119536
Clin Cancer Res. 2014 Nov 15;20(22):5796-807
pubmed: 25212607
J Clin Invest. 2015 Jan;125(1):316-23
pubmed: 25485683
Blood. 2015 May 14;125(20):3049-58
pubmed: 25838343
Annu Rev Immunol. 2015;33:417-43
pubmed: 25861977
J Clin Invest. 1989 Dec;84(6):2008-11
pubmed: 2592570
Immun Inflamm Dis. 2015 Jun;3(2):94-102
pubmed: 26029369
Crit Rev Oncol Hematol. 2015 Nov;96(2):339-54
pubmed: 26123319
Oncoimmunology. 2015 Feb 3;4(5):e1005460
pubmed: 26155400
Exp Hematol Oncol. 2015 Aug 05;4:21
pubmed: 26251761
Oncotarget. 2015 Jul 20;6(20):17958-67
pubmed: 26255628
Neoplasma. 2015;62(5):827-32
pubmed: 26278155
Oncotarget. 2015 Dec 22;6(41):43267-80
pubmed: 26657115
Blood. 1989 Jul;74(1):380-7
pubmed: 2665838
Immunol Lett. 2016 Nov;179:2-8
pubmed: 26844414
N Engl J Med. 2016 Feb 11;374(6):555-61
pubmed: 26863356
Clin Lymphoma Myeloma Leuk. 2016 Jun;16(6):e71-7
pubmed: 27013181
J Clin Oncol. 2016 Aug 10;34(23):2698-704
pubmed: 27269947
J Allergy Clin Immunol. 2017 Jan;139(1):335-346.e3
pubmed: 27372564
Leukemia. 2017 Feb;31(2):373-381
pubmed: 27400413
Immunology. 2017 Mar;150(3):265-275
pubmed: 27935637
Curr Cancer Drug Targets. 2017;17(9):806-818
pubmed: 28201978
Oncotarget. 2017 May 23;8(21):35088-35102
pubmed: 28456791
Leuk Lymphoma. 2018 Jan;59(1):178-186
pubmed: 28540748
Leuk Lymphoma. 2018 Jan;59(1):221-224
pubmed: 28554253
JCI Insight. 2017 Oct 5;2(19):
pubmed: 28978808
Front Immunol. 2017 Oct 16;8:1298
pubmed: 29085366
Mediators Inflamm. 2017;2017:1852517
pubmed: 29089667
Front Immunol. 2017 Oct 19;8:1347
pubmed: 29098000
JCI Insight. 2018 Apr 19;3(8):null
pubmed: 29669929
Oncoimmunology. 2018 Mar 19;7(7):e1444411
pubmed: 29900053
J Cancer. 2018 Jun 4;9(12):2211-2214
pubmed: 29937941
Cell. 2018 Aug 23;174(5):1054-1066
pubmed: 30142344
Immunol Rev. 2018 Nov;286(1):37-52
pubmed: 30294963
Eur J Immunol. 2019 Jan;49(1):11-18
pubmed: 30350853
Front Pharmacol. 2018 Nov 06;9:1157
pubmed: 30459597
Front Oncol. 2018 Nov 06;8:508
pubmed: 30460198
Biomolecules. 2018 Dec 20;9(1):
pubmed: 30577568
Clin Exp Immunol. 1988 Aug;73(2):214-8
pubmed: 3263229
Blood. 1995 Oct 1;86(7):2789-98
pubmed: 7545472
Blood. 1995 Nov 15;86(10):3915-21
pubmed: 7579361
Blood. 1995 Oct 15;86(8):3043-9
pubmed: 7579398
Br J Haematol. 1993 Jan;83(1):63-7
pubmed: 7679588
Br J Haematol. 1994 Sep;88(1):17-23
pubmed: 7803239
Br J Haematol. 1995 Feb;89(2):243-9
pubmed: 7873373
J Immunol. 1994 Aug 15;153(4):1697-706
pubmed: 7913943
Blood. 1994 Oct 1;84(7):2269-77
pubmed: 7919345
Mayo Clin Proc. 1994 Jul;69(7):680-3
pubmed: 8015334
Clin Exp Metastasis. 1993 Mar;11(2):213-26
pubmed: 8095198
Br J Haematol. 1994 Feb;86(2):439-40
pubmed: 8199045
Leuk Lymphoma. 1993 Apr;9(6):441-52
pubmed: 8339050
Eur J Immunol. 1993 Apr;23(4):820-4
pubmed: 8458373
Clin Exp Immunol. 1993 Apr;92(1):27-31
pubmed: 8467562
Blood. 1993 May 15;81(10):2658-63
pubmed: 8490175
Blood. 1996 Jan 15;87(2):746-55
pubmed: 8555499
Blood. 1996 Feb 1;87(3):1104-12
pubmed: 8562936
Blood. 1996 Apr 15;87(8):3297-306
pubmed: 8605346
Blood. 1996 Mar 15;87(6):2095-147
pubmed: 8630372
Leukemia. 1996 May;10(5):866-76
pubmed: 8656685
Med Oncol. 1996 Mar;13(1):1-7
pubmed: 8869933
Leuk Lymphoma. 1996 Mar;21(1-2):31-6
pubmed: 8907266
Blood. 1997 Jan 1;89(1):219-26
pubmed: 8978295
J Cell Biol. 1996 Dec;135(6 Pt 1):1457-70
pubmed: 8978815
Cell. 1997 Jan 10;88(1):97-107
pubmed: 9019411
Leuk Lymphoma. 1996 Dec;24(1-2):111-20
pubmed: 9049967
Hematol Oncol Clin North Am. 1997 Feb;11(1):27-42
pubmed: 9081202
Hematol Oncol Clin North Am. 1997 Feb;11(1):71-87
pubmed: 9081205
Am J Hematol. 1997 Apr;54(4):335-7
pubmed: 9092693
J Immunol. 1997 Apr 1;158(7):3359-65
pubmed: 9120294
Acta Haematol. 1997;97(4):191-5
pubmed: 9158660
Med Hypotheses. 1997 May;48(5):415-21
pubmed: 9185130
Science. 1997 Jun 20;276(5320):1851-4
pubmed: 9188529
Virology. 1997 Jun 9;232(2):369-78
pubmed: 9191851
Leukemia. 1997 Aug;11(8):1312-7
pubmed: 9264386
J Clin Invest. 1998 Mar 15;101(6):1441-52
pubmed: 9502787
Curr Opin Hematol. 1998 Jan;5(1):42-8
pubmed: 9515202
Leukemia. 1998 Apr;12(4):593-600
pubmed: 9557619
Cancer. 1998 May 15;82(10):1860-6
pubmed: 9587117
Exp Hematol. 1998 Jul;26(7):597-603
pubmed: 9657134