Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 06 2019
11 06 2019
Historique:
received:
10
02
2019
accepted:
20
05
2019
entrez:
13
6
2019
pubmed:
13
6
2019
medline:
21
10
2020
Statut:
epublish
Résumé
The number of brown adipocytes residing within murine white fat depots (brite adipocytes) varies a lot by depot, strain and physiological condition. Several endocrine fibroblast growth factors are implicated in the regulation of brite adipocyte abundance. The family of fibroblast growth factors can be categorized by their site of action into endocrine, paracrine and intracellular peptides. We here screened paracrine fibroblast growth factors for their potential to drive brite adipogenesis in differentiating epididymal white adipocytes and identified fibroblast growth factor 8b to induce uncoupling protein 1 expression, but at the same time to interfere in adipogenesis. In an in vivo trial, fibroblast growth factor 8b released into the epididymal fat depot failed to robustly increase the number of brite adipocytes. The specific action of fibroblast growth factor 8b on the uncoupling protein 1 promoter in cultured epididymal adipocytes provides a model system to dissect specific gene regulatory networks.
Identifiants
pubmed: 31186471
doi: 10.1038/s41598-019-44878-w
pii: 10.1038/s41598-019-44878-w
pmc: PMC6560125
doi:
Substances chimiques
PPAR gamma
0
RNA, Messenger
0
Uncoupling Protein 1
0
Fibroblast Growth Factor 8
148997-75-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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