ACTH-producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review.
Mediastinal carcinoid
mental disorder
neuroendocrine carcinoma
pulmonary metastasis
severe psychosis
Journal
Thoracic cancer
ISSN: 1759-7714
Titre abrégé: Thorac Cancer
Pays: Singapore
ID NLM: 101531441
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
07
04
2019
revised:
30
04
2019
accepted:
03
05
2019
pubmed:
13
6
2019
medline:
21
7
2020
entrez:
13
6
2019
Statut:
ppublish
Résumé
A 32-year-old woman was referred to our hospital because of severe psychosis and was found to have an ectopic ACTH-producing thymic neuroendocrine tumor. Laboratory data revealed an elevated serum cortisol and plasma ACTH level, hypokalemia, and metabolic alkalosis. Chest computed tomography (CT) revealed an anterior mediastinal mass and multiple pulmonary nodules. As the patient was unable to communicate because of her consciousness disturbance, she was managed with artificial ventilation and deep sedation. Metyrapone and potassium supplementation were administered, and steroid psychosis gradually improved. Thoracic surgery was performed and the histopathological diagnosis was thymic neuroendocrine tumor with positive anti-ACTH immunohistochemical staining. Here we present details of the case and review the literature.
Identifiants
pubmed: 31187563
doi: 10.1111/1759-7714.13099
pmc: PMC6610259
doi:
Substances chimiques
Adrenocorticotropic Hormone
9002-60-2
Potassium
RWP5GA015D
Metyrapone
ZS9KD92H6V
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1648-1653Informations de copyright
© 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
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