Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease.
7-ketocholesterol
Sickle cell disease
cholestane-3β,5α,6β-triol
lipid profile
oxysterol
Journal
Scandinavian journal of clinical and laboratory investigation
ISSN: 1502-7686
Titre abrégé: Scand J Clin Lab Invest
Pays: England
ID NLM: 0404375
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
pubmed:
13
6
2019
medline:
20
6
2020
entrez:
13
6
2019
Statut:
ppublish
Résumé
Sickle cell disease (SCD) causes anemia, oxidative stress, chronic inflammation, and lipid abnormalities. Oxysterols are oxidized derivatives of cholesterol and affect cholesterol metabolism and eryptosis. Our aim was to determine whether the plasma concentrations of 7-ketocholesterol (7-KC) and cholestane-3β,5α,6β-triol (C-triol) were associated with hemolysis and lipid profile in patients with SCD. A total of 32 steady-state pediatric patients with SCD (22 HbSS and 10 HbSß
Identifiants
pubmed: 31187639
doi: 10.1080/00365513.2019.1627578
doi:
Substances chimiques
Cholestanols
0
Ketocholesterols
0
Lipids
0
Pyrimidines
0
cholestane-3,5,6-triol
115510-05-9
OT-24
55083-70-0
Ferritins
9007-73-2
Cholesterol
97C5T2UQ7J
Iron
E1UOL152H7
7-ketocholesterol
O7676FE78M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM