Distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy among diabetic patients in Ilorin: Prevalence and predictors.
Adult
Aged
Aged, 80 and over
Autonomic Nervous System Diseases
/ complications
Cardiovascular Diseases
/ epidemiology
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ physiopathology
Diabetic Neuropathies
/ complications
Humans
Middle Aged
Nigeria
/ epidemiology
Polyneuropathies
/ complications
Prevalence
Severity of Illness Index
Diabetic neuropathy
predictors
prevalence
Journal
The Nigerian postgraduate medical journal
ISSN: 1117-1936
Titre abrégé: Niger Postgrad Med J
Pays: Nigeria
ID NLM: 9613595
Informations de publication
Date de publication:
Historique:
entrez:
13
6
2019
pubmed:
13
6
2019
medline:
21
6
2019
Statut:
ppublish
Résumé
Peripheral neuropathy contributes to morbidity and mortality among diabetic patients. We aimed to determine the prevalence of distal symmetrical polyneuropathy (DSP) and cardiovascular autonomic neuropathy (CAN) and their predictors among diabetic patients in Ilorin, North-central Nigeria. : This was a cross-sectional study in which 175 consenting diabetic patients were recruited consecutively. We assessed DSP using the Michigan Neuropathy Screening Instrument (MNSI), and it was defined by MNSI symptom score ≥7 or physical examination score ≥2. CAN was assessed using five tests of cardiovascular autonomic function, and abnormalities in ≥2 tests defined CAN. Logistic regression analysis was used to identify the predictors of DSP and CAN. The prevalence of DSP and CAN was 41.7% and 26.9%, respectively, while 19.4% had both. Hypertension (odds ratio [OR]: 2.401; 95% confidence interval [CI]: 1.169-4.930, P = 0.017) and poor glycaemic control (OR: 2.957; 95% CI: 1.488-5.878, P = 0.002) independently predicted DSP. Hypertension (OR: 2.215; 95% CI: 1.023-4.414, P = 0.043) and serum creatinine (OR: 1.035; 95% CI: 1.014-1.056, P ≤ 0.001) were independent predictors of CAN. DSP and CAN are common among diabetic patients, and thus efforts should be made to prevent their occurrence by intensifying blood pressure and glucose control while regularly monitoring renal function.
Sections du résumé
BACKGROUND
BACKGROUND
Peripheral neuropathy contributes to morbidity and mortality among diabetic patients.
OBJECTIVES
OBJECTIVE
We aimed to determine the prevalence of distal symmetrical polyneuropathy (DSP) and cardiovascular autonomic neuropathy (CAN) and their predictors among diabetic patients in Ilorin, North-central Nigeria.
MATERIALS AND METHODS
METHODS
: This was a cross-sectional study in which 175 consenting diabetic patients were recruited consecutively. We assessed DSP using the Michigan Neuropathy Screening Instrument (MNSI), and it was defined by MNSI symptom score ≥7 or physical examination score ≥2. CAN was assessed using five tests of cardiovascular autonomic function, and abnormalities in ≥2 tests defined CAN. Logistic regression analysis was used to identify the predictors of DSP and CAN.
RESULTS
RESULTS
The prevalence of DSP and CAN was 41.7% and 26.9%, respectively, while 19.4% had both. Hypertension (odds ratio [OR]: 2.401; 95% confidence interval [CI]: 1.169-4.930, P = 0.017) and poor glycaemic control (OR: 2.957; 95% CI: 1.488-5.878, P = 0.002) independently predicted DSP. Hypertension (OR: 2.215; 95% CI: 1.023-4.414, P = 0.043) and serum creatinine (OR: 1.035; 95% CI: 1.014-1.056, P ≤ 0.001) were independent predictors of CAN.
CONCLUSION
CONCLUSIONS
DSP and CAN are common among diabetic patients, and thus efforts should be made to prevent their occurrence by intensifying blood pressure and glucose control while regularly monitoring renal function.
Identifiants
pubmed: 31187753
pii: NigerPostgradMedJ_2019_26_2_123_259916
doi: 10.4103/npmj.npmj_30_19
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-128Déclaration de conflit d'intérêts
None