Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results From the META Longitudinal Cohort Study.
Acquired Immunodeficiency Syndrome
/ drug therapy
Adult
Age Factors
Anti-HIV Agents
/ therapeutic use
Biomarkers
CD4 Lymphocyte Count
Female
Fibrin Fibrinogen Degradation Products
/ analysis
HIV-1
/ genetics
Humans
Inflammation
/ drug therapy
Interleukin-6
/ blood
Lipopolysaccharide Receptors
/ blood
Longitudinal Studies
Male
Medication Adherence
Sex Factors
South Africa
Time Factors
Uganda
Viral Load
/ genetics
HIV
South Africa
Uganda
antiretroviral therapy
immune activation
inflammation
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
30 08 2019
30 08 2019
Historique:
received:
27
02
2019
accepted:
16
05
2019
pubmed:
13
6
2019
medline:
28
5
2020
entrez:
13
6
2019
Statut:
ppublish
Résumé
Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) initiation, among individuals starting ART during earlier-stage (CD4 T-cell count >350/µL) or late-stage disease (CD4 T-cell count <200/µL). Female sex, older age, viral load, and late-stage disease were associated with pre-ART biomarkers (n = 661; P < .05). However, there were no differences in biomarkers by disease stage after 12 months of ART (n = 438; P > .05), owing to loss from observation and greater declines in biomarkers in late-stage initiators (P < .001). Earlier initiation of ART is associated with decreased inflammation, but levels seem to converge between earlier and later initiators surviving to 12 months.
Identifiants
pubmed: 31188451
pii: 5514246
doi: 10.1093/infdis/jiz259
pmc: PMC6736121
doi:
Substances chimiques
Anti-HIV Agents
0
Biomarkers
0
CD14 protein, human
0
Fibrin Fibrinogen Degradation Products
0
IL6 protein, human
0
Interleukin-6
0
Lipopolysaccharide Receptors
0
fibrin fragment D
0
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1172-1177Subventions
Organisme : NIMH NIH HHS
ID : K23 MH099916
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125498
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027763
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141053
Pays : United States
Investigateurs
Norma Ware
(N)
Tumwesigye Elioda
(T)
Alexander C Tsai
(AC)
Lynn Matthews
(L)
Monique Wyatt
(M)
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
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