Molecular Signature of Asthma-Enhanced Sensitivity to CuO Nanoparticle Aerosols from 3D Cell Model.


Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
25 06 2019
Historique:
pubmed: 13 6 2019
medline: 28 8 2020
entrez: 13 6 2019
Statut: ppublish

Résumé

More than 5% of any population suffers from asthma, and there are indications that these individuals are more sensitive to nanoparticle aerosols than the healthy population. We used an air-liquid interface model of inhalation exposure to investigate global transcriptomic responses in reconstituted three-dimensional airway epithelia of healthy and asthmatic subjects exposed to pristine (nCuO) and carboxylated (nCuO

Identifiants

pubmed: 31188557
doi: 10.1021/acsnano.9b01823
pmc: PMC6750904
doi:

Substances chimiques

Aerosols 0
Copper 789U1901C5
cupric oxide V1XJQ704R4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6932-6946

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Auteurs

Ingeborg Kooter (I)

The Netherlands Organization for Applied Scientific Research, TNO , P.O. Box 80015, Utrecht 3584 CB , The Netherlands.

Marit Ilves (M)

Human Microbiome Research, Faculty of Medicine , University of Helsinki , P.O. Box 21, Helsinki 00290 , Finland.

Mariska Gröllers-Mulderij (M)

The Netherlands Organization for Applied Scientific Research, TNO , P.O. Box 80015, Utrecht 3584 CB , The Netherlands.

Evert Duistermaat (E)

Triskelion B.V. , P.O. Box 844, Zeist 3704 HE , The Netherlands.

Peter C Tromp (PC)

The Netherlands Organization for Applied Scientific Research, TNO , P.O. Box 80015, Utrecht 3584 CB , The Netherlands.

Frieke Kuper (F)

The Netherlands Organization for Applied Scientific Research, TNO , P.O. Box 80015, Utrecht 3584 CB , The Netherlands.

Pia Kinaret (P)

Faculty of Medicine and Life Sciences , University of Tampere , Tampere FI-33014 , Finland.
Institute of Biotechnology , University of Helsinki , P.O. Box 56, Helsinki 00014 , Finland.

Kai Savolainen (K)

Finnish Institute of Occupational Health , P.O. Box 40, Helsinki 00014 , Finland.

Dario Greco (D)

Faculty of Medicine and Life Sciences , University of Tampere , Tampere FI-33014 , Finland.
Institute of Biotechnology , University of Helsinki , P.O. Box 56, Helsinki 00014 , Finland.

Piia Karisola (P)

Human Microbiome Research, Faculty of Medicine , University of Helsinki , P.O. Box 21, Helsinki 00290 , Finland.

Joseph Ndika (J)

Human Microbiome Research, Faculty of Medicine , University of Helsinki , P.O. Box 21, Helsinki 00290 , Finland.

Harri Alenius (H)

Human Microbiome Research, Faculty of Medicine , University of Helsinki , P.O. Box 21, Helsinki 00290 , Finland.
Institute of Environmental Medicine , Karolinska Institutet , P.O. Box 210, Stockholm SE-17176 , Sweden.

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Classifications MeSH