A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions.
Animals
Autonomic Nervous System
/ physiology
Calcium
/ metabolism
Cells, Cultured
Endothelial Cells
/ metabolism
Humans
Lymphatic Vessels
/ cytology
Male
Mice
Mice, Inbred C57BL
Muscle Contraction
Myocytes, Smooth Muscle
/ metabolism
Neoplasms, Experimental
/ physiopathology
Nitric Oxide
/ metabolism
Receptors, Adrenergic
/ metabolism
Ca(2+) imaging
autonomic nervous system
contractility
lymphatic vessels
tumor-draining lymphatics
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
11 06 2019
11 06 2019
Historique:
received:
15
08
2018
revised:
22
02
2019
accepted:
15
05
2019
entrez:
13
6
2019
pubmed:
13
6
2019
medline:
4
8
2020
Statut:
ppublish
Résumé
Lymphatic vessels (LVs) are important in the regulation of tissue fluid homeostasis and the pathogenesis of tumor progression. We investigated the innervation of LVs and the response to agonists and antagonists of the autonomic nervous system in vivo. While skin-draining collecting LVs express muscarinic, α
Identifiants
pubmed: 31189113
pii: S2211-1247(19)30679-5
doi: 10.1016/j.celrep.2019.05.050
pmc: PMC6581737
pii:
doi:
Substances chimiques
Receptors, Adrenergic
0
Nitric Oxide
31C4KY9ESH
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3305-3314.e13Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.