Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA-NF-κB.
Amides
/ administration & dosage
Animals
Carcinoma, Lewis Lung
/ complications
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cisplatin
/ adverse effects
Disease Models, Animal
Gene Expression Regulation
/ drug effects
Humans
Mice
NF-kappa B
/ metabolism
Peripheral Nervous System Diseases
/ chemically induced
Proteomics
/ methods
Pyridines
/ administration & dosage
Signal Transduction
/ drug effects
Xenograft Model Antitumor Assays
rhoA GTP-Binding Protein
/ metabolism
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
08
01
2019
revised:
23
04
2019
accepted:
07
06
2019
pubmed:
14
6
2019
medline:
18
6
2020
entrez:
14
6
2019
Statut:
ppublish
Résumé
Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of cancer therapy that frequently requires a reduction or cessation of treatments and negatively impacts the patient's quality of life. There is currently no effective means to prevent or treat CIPN. In this study, we developed and applied CIPN in an immunocompetent, syngeneic murine Lewis Lung Carcinoma (LLCab) model that enabled the elucidation of both tumor and host responses to cisplatin and treatments of Y-27632, a selective inhibitor of Rho kinase/p160
Identifiants
pubmed: 31189689
pii: 1541-7786.MCR-19-0024
doi: 10.1158/1541-7786.MCR-19-0024
pmc: PMC6774348
mid: NIHMS1531869
doi:
Substances chimiques
Amides
0
NF-kappa B
0
Pyridines
0
RHOA protein, human
124671-05-2
Y 27632
138381-45-0
rhoA GTP-Binding Protein
EC 3.6.5.2
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1910-1919Subventions
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA111891
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM146257
Pays : United States
Organisme : NCI NIH HHS
ID : R15 CA165202
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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