Marek's Disease Virus-Encoded MicroRNA 155 Ortholog Critical for the Induction of Lymphomas Is Not Essential for the Proliferation of Transformed Cell Lines.
CRISPR/Cas9 editing
Marek's disease virus
microRNA
oncogenesis
transformation
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
01 09 2019
01 09 2019
Historique:
received:
30
04
2019
accepted:
05
06
2019
pubmed:
14
6
2019
medline:
3
6
2020
entrez:
14
6
2019
Statut:
epublish
Résumé
MicroRNAs (miRNAs) are small noncoding RNAs with profound regulatory roles in many areas of biology, including cancer. MicroRNA 155 (miR-155), one of the extensively studied multifunctional miRNAs, is important in several human malignancies such as diffuse large B cell lymphoma and chronic lymphocytic leukemia. Moreover, miR-155 orthologs KSHV-miR-K12-11 and MDV-miR-M4, encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) and Marek's disease virus (MDV), respectively, are also involved in oncogenesis. In MDV-induced T-cell lymphomas and in lymphoblastoid cell lines derived from them, MDV-miR-M4 is highly expressed. Using excellent disease models of infection in natural avian hosts, we showed previously that MDV-miR-M4 is critical for the induction of T-cell lymphomas as mutant viruses with precise deletions were significantly compromised in their oncogenicity. However, those studies did not elucidate whether continued expression of MDV-miR-M4 is essential for maintaining the transformed phenotype of tumor cells. Here using an
Identifiants
pubmed: 31189706
pii: JVI.00713-19
doi: 10.1128/JVI.00713-19
pmc: PMC6694823
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007032
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R007632/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R007896/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Zhang et al.
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