Electric field dynamics in the brain during multi-electrode transcranial electric stimulation.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 06 2019
12 06 2019
Historique:
received:
15
06
2018
accepted:
20
05
2019
entrez:
14
6
2019
pubmed:
14
6
2019
medline:
6
7
2019
Statut:
epublish
Résumé
Neural oscillations play a crucial role in communication between remote brain areas. Transcranial electric stimulation with alternating currents (TACS) can manipulate these brain oscillations in a non-invasive manner. Recently, TACS using multiple electrodes with phase shifted stimulation currents were developed to alter long-range connectivity. Typically, an increase in coordination between two areas is assumed when they experience an in-phase stimulation and a disorganization through an anti-phase stimulation. However, the underlying biophysics of multi-electrode TACS has not been studied in detail. Here, we leverage direct invasive recordings from two non-human primates during multi-electrode TACS to characterize electric field magnitude and phase as a function of the phase of stimulation currents. Further, we report a novel "traveling wave" stimulation where the location of the electric field maximum changes over the stimulation cycle. Our results provide a mechanistic understanding of the biophysics of multi-electrode TACS and enable future developments of novel stimulation protocols.
Identifiants
pubmed: 31189931
doi: 10.1038/s41467-019-10581-7
pii: 10.1038/s41467-019-10581-7
pmc: PMC6561925
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2573Subventions
Organisme : NIMH NIH HHS
ID : R01 MH111439
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH110217
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH109429
Pays : United States
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