The Mitochondrial Permeability Transition in Mitochondrial Disorders.

Animals Humans Mitochondrial Diseases / metabolism Mitochondrial Membrane Transport Proteins / metabolism Mitochondrial Membranes / metabolism Mitochondrial Permeability Transition Pore

Journal

Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826

Informations de publication

Date de publication:
2019
Historique:
received: 24 01 2019
revised: 15 03 2019
accepted: 01 04 2019
entrez: 14 6 2019
pubmed: 14 6 2019
medline: 18 12 2019
Statut: epublish

Résumé

Mitochondrial permeability transition pore (PTP), a (patho)physiological phenomenon discovered over 40 years ago, is still not completely understood. PTP activation results in a formation of a nonspecific channel within the inner mitochondrial membrane with an exclusion size of 1.5 kDa. PTP openings can be transient and are thought to serve a physiological role to allow quick Ca

Identifiants

DOI: 10.1155/2019/3403075 PMID: 31191798 PMC: PMC6525910
pubmed: 31191798
doi: 10.1155/2019/3403075
pmc: PMC6525910
doi:

Substances chimiques

Mitochondrial Membrane Transport Proteins 0
Mitochondrial Permeability Transition Pore 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

3403075

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Auteurs

Justina Šileikytė (J)

Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
ORCID: 0000-0002-6795-6344

Michael Forte (M)

Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
ORCID: 0000-0003-3972-7154

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Mitochondrial Permeability Transition in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Mitochondrial Permeability Transition in...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies mitochondriales › The Mitochondrial Permeability Transition in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › The Mitochondrial Permeability Transition in...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Membranes intracellulaires › Membranes mitochondriales › The Mitochondrial Permeability Transition in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › Pore de transition de perméabilité mitochondriale › The Mitochondrial Permeability Transition in...