Interleukin 1 is a key driver of inflammatory bowel disease-demonstration in a murine IL-1Ra knockout model.
IL-1Ra deficient
inflammatory bowel disease
intestinal enzymes
matrix-degrading enzymes
pro-inflammatory cytokines
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
28 May 2019
28 May 2019
Historique:
received:
23
10
2018
accepted:
03
04
2019
entrez:
14
6
2019
pubmed:
14
6
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Interleukin 1 (IL-1) is an important mediator of inflammation and tissue damage in inflammatory bowel disease (IBD). The balance between IL-1 and IL-1Ra as a natural inhibitor plays a vital role in a variety of diseases. Here, we investigated whether changes seen during IBD are induced spontaneously in mice lacking a functional
Identifiants
pubmed: 31191826
doi: 10.18632/oncotarget.26894
pii: 26894
pmc: PMC6544399
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3559-3575Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors declare no conflicts of interest.
Références
J Exp Med. 2000 Jan 17;191(2):303-12
pubmed: 10637274
J Clin Invest. 2001 Mar;107(6):695-702
pubmed: 11254669
Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G922-9
pubmed: 11292601
Cytokine Growth Factor Rev. 2002 Aug-Oct;13(4-5):323-40
pubmed: 12220547
Am J Pathol. 2003 Apr;162(4):1355-60
pubmed: 12651627
Gastroenterology. 1992 Nov;103(5):1587-95
pubmed: 1426879
Clin Exp Immunol. 2004 Nov;138(2):323-9
pubmed: 15498044
Gut. 2004 Dec;53(12):1724-5
pubmed: 15542502
Folia Morphol (Warsz). 2004 Nov;63(4):423-30
pubmed: 15712138
Arthritis Res Ther. 2005;7(4):R732-45
pubmed: 15987475
J Exp Med. 2006 Mar 20;203(3):541-52
pubmed: 16505137
Semin Cell Dev Biol. 2008 Feb;19(1):34-41
pubmed: 17707664
J Immunol. 2008 Apr 15;180(8):5653-61
pubmed: 18390750
Clin Exp Immunol. 2009 Feb;155(2):257-65
pubmed: 19137636
Differentiation. 2009 Jan;77(1):84-94
pubmed: 19281767
Cytokine. 2010 Mar;49(3):279-86
pubmed: 20034811
J Exp Med. 2010 May 10;207(5):1057-66
pubmed: 20439544
J Clin Invest. 1990 Sep;86(3):972-80
pubmed: 2168444
Regul Pept. 2012 Aug 20;177(1-3):40-5
pubmed: 22561447
J Crohns Colitis. 2013 May;7(4):286-300
pubmed: 22578910
J Exp Med. 2012 Aug 27;209(9):1595-609
pubmed: 22891275
Am J Physiol Gastrointest Liver Physiol. 2013 May 1;304(9):G793-803
pubmed: 23471340
Gut. 2014 Apr;63(4):578-87
pubmed: 23525573
Gastroenterol Res Pract. 2013;2013:431231
pubmed: 23737764
Immunity. 2013 Dec 12;39(6):1003-18
pubmed: 24332029
Eur J Pharmacol. 2015 Jul 15;759:253-64
pubmed: 25814256
Am J Pathol. 2015 Jun;185(6):1624-37
pubmed: 25864926
Mediators Inflamm. 2015;2015:964131
pubmed: 25948887
Cell Mol Gastroenterol Hepatol. 2015 Mar 1;1(2):154-170
pubmed: 26000334
World J Gastroenterol. 2016 Mar 21;22(11):3117-26
pubmed: 27003989
J Surg Res. 2016 May 1;202(1):225-34
pubmed: 27083970
Gut. 1989 Jun;30(6):835-8
pubmed: 2787769
Mediators Inflamm. 2017;2017:9074601
pubmed: 28316376
Mediators Inflamm. 2017;2017:4810258
pubmed: 28420941
Am J Gastroenterol. 1983 Sep;78(9):537-47
pubmed: 6613965
Gut. 1984 Jun;25(6):665-72
pubmed: 6735250
J Immunol. 1995 Mar 1;154(5):2434-40
pubmed: 7868909
Gut. 1993 Dec;34(12):1705-9
pubmed: 8031350
J Clin Invest. 1994 Jul;94(1):449-53
pubmed: 8040288
Gastroenterology. 1994 Apr;106(4):960-72
pubmed: 8144001
Gut. 1994 Jan;35(1):68-72
pubmed: 8307453
Reg Immunol. 1993 Jan-Feb;5(1):11-7
pubmed: 8347466
Clin Exp Immunol. 1993 Oct;94(1):174-81
pubmed: 8403503
J Biol Chem. 1996 Jan 12;271(2):1237-42
pubmed: 8557656
Cell Immunol. 1996 Mar 15;168(2):276-80
pubmed: 8640875
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11008-13
pubmed: 8855299
Gastroenterology. 1998 Jul;115(1):182-205
pubmed: 9649475