Immunomodulatory Effects of the Neuropeptide Pituitary Adenylate Cyclase-Activating Polypeptide in Acute

Animals Antigens, Ly Brain-Derived Neurotrophic Factor / metabolism Chemokines / metabolism Cytokines / metabolism Disease Models, Animal Female Host-Pathogen Interactions / immunology Immunity, Innate Immunomodulation Inflammation Interleukin-10 Macrophages Mice Mice, Inbred C57BL Nerve Growth Factors Neuropeptides / immunology Pituitary Adenylate Cyclase-Activating Polypeptide / administration & dosage Receptors, Vasoactive Intestinal Peptide, Type II Receptors, Vasoactive Intestinal Polypeptide, Type I Toxoplasma Toxoplasmosis / immunology Up-Regulation
Toxoplasma gondii acute infection innate immunity macrophages monocytes neurotrophins pituitary adenylate cyclase-activating polypeptide (PACAP)

Journal

Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359

Informations de publication

Date de publication:
2019
Historique:
received: 31 01 2019
accepted: 26 04 2019
entrez: 14 6 2019
pubmed: 14 6 2019
medline: 28 1 2020
Statut: epublish

Résumé

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is an endogenous neuropeptide with distinct functions including the regulation of inflammatory processes. PACAP is able to modify the immune response by directly regulating macrophages and monocytes inhibiting the production of inflammatory cytokines, chemokines and free radicals. Here, we analyzed the effect of exogenous PACAP on peripheral immune cell subsets upon acute infection with the parasite

Identifiants

DOI: 10.3389/fcimb.2019.00154 PMID: 31192159 PMC: PMC6546896
pubmed: 31192159
doi: 10.3389/fcimb.2019.00154
pmc: PMC6546896
doi:

Substances chimiques

Antigens, Ly 0
Brain-Derived Neurotrophic Factor 0
Chemokines 0
Cytokines 0
IL10 protein, mouse 0
Ly-6C antigen, mouse 0
Nerve Growth Factors 0
Neuropeptides 0
Pituitary Adenylate Cyclase-Activating Polypeptide 0
Receptors, Vasoactive Intestinal Peptide, Type II 0
Receptors, Vasoactive Intestinal Polypeptide, Type I 0
Interleukin-10 130068-27-8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

154

Références

PLoS Pathog. 2014 Apr 10;10(4):e1004047
pubmed: 24722202
PLoS Biol. 2015 Nov 13;13(11):e1002288
pubmed: 26565995
Am J Pathol. 2006 Apr;168(4):1179-88
pubmed: 16565493
Curr Protein Pept Sci. 2002 Aug;3(4):423-39
pubmed: 12370005
Front Cell Infect Microbiol. 2017 Jun 21;7:259
pubmed: 28680853
Dev Neurosci. 2002;24(1):14-23
pubmed: 12145407
Nature. 2013 Oct 10;502(7470):245-8
pubmed: 24037376
Neuroreport. 2001 Apr 17;12(5):919-23
pubmed: 11303760
Cell Calcium. 2008 Mar;43(3):270-84
pubmed: 17651798
Cell Signal. 2007 Jan;19(1):152-62
pubmed: 16914291
J Neurosci Res. 2005 Feb 15;79(4):476-87
pubmed: 15635609
Biochim Biophys Acta. 1997 Dec 12;1359(3):250-62
pubmed: 9434131
Eur J Pharmacol. 2004 Oct 1;500(1-3):453-65
pubmed: 15464052
J Immunol. 1999 Feb 15;162(4):2358-67
pubmed: 9973516
PLoS Pathog. 2011 Sep;7(9):e1002236
pubmed: 21931552
Pharmacol Rev. 2004 Jun;56(2):249-90
pubmed: 15169929
J Cell Sci. 1995 Jun;108 ( Pt 6):2457-64
pubmed: 7673360
J Neuroimmunol. 1998 May 15;85(2):155-67
pubmed: 9630164
Regul Pept. 1996 Apr 23;62(2-3):161-6
pubmed: 8795080
Gastroenterology. 2003 Apr;124(4):961-71
pubmed: 12671893
J Leukoc Biol. 1998 May;63(5):591-601
pubmed: 9581803
J Immunol. 2001 Sep 15;167(6):3182-9
pubmed: 11544304
Cell. 1996 Mar 22;84(6):933-9
pubmed: 8601316
Cell Host Microbe. 2010 Dec 16;8(6):484-95
pubmed: 21147463
J Neuroimmune Pharmacol. 2014 Dec;9(5):615-28
pubmed: 25239528
Peptides. 2007 Sep;28(9):1713-9
pubmed: 17719696
Regul Pept. 2005 Mar 15;126(1-2):123-8
pubmed: 15620425
J Neuroinflammation. 2016 Apr 22;13(1):88
pubmed: 27102880
Peptides. 2007 Sep;28(9):1746-52
pubmed: 17544170
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2568-73
pubmed: 20133793
J Immunol. 2005 Dec 1;175(11):7311-24
pubmed: 16301637
PLoS One. 2014 Sep 19;9(9):e108389
pubmed: 25238233
F1000Res. 2016 Jul 28;5:
pubmed: 27540475
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1053-8
pubmed: 11792830
J Exp Med. 2005 Jun 6;201(11):1761-9
pubmed: 15928200
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2012-7
pubmed: 19190179
Parasite Immunol. 2015 Mar;37(3):150-8
pubmed: 25573476
J Immunol. 2015 Apr 1;194(7):3223-35
pubmed: 25710908
J Biol Chem. 1999 Nov 5;274(45):31930-40
pubmed: 10542221
Front Immunol. 2015 May 19;6:225
pubmed: 26042120
Cell Death Differ. 2009 Mar;16(3):406-16
pubmed: 19057622
J Biol Chem. 1998 Nov 20;273(47):31427-36
pubmed: 9813054
Ann N Y Acad Sci. 2003 May;992:141-57
pubmed: 12794054
Clin Exp Immunol. 2008 Mar;151(3):476-86
pubmed: 18190610
Cell Microbiol. 2015 Jul;17(7):1069-83
pubmed: 25628099
Clin Sci (Lond). 2017 Jan 1;131(1):13-23
pubmed: 27908981
Cell Microbiol. 2006 Apr;8(4):535-44
pubmed: 16548880
Endocr Rev. 2000 Dec;21(6):619-70
pubmed: 11133067
Immunity. 2008 Aug 15;29(2):306-17
pubmed: 18691912
Clin Exp Allergy. 2008 Jul;38(7):1168-73
pubmed: 18477014
PLoS One. 2010 Dec 01;5(12):e15053
pubmed: 21152021
Glia. 2019 Jan;67(1):193-211
pubmed: 30597659
Science. 1988 Apr 22;240(4851):516-8
pubmed: 3128869
J Leukoc Biol. 2004 Jun;75(6):1122-30
pubmed: 15020654
Nat Rev Immunol. 2012 Apr 25;12(5):367-82
pubmed: 22531325
Pharmacol Rep. 2005 May-Jun;57(3):307-20
pubmed: 15985713
Brain Behav Immun. 2010 May;24(4):585-97
pubmed: 20083190
Neuropeptides. 1996 Dec;30(6):583-95
pubmed: 9004257
Eur J Microbiol Immunol (Bp). 2012 Jun;2(2):97-102
pubmed: 24672677
Infect Immun. 2010 Apr;78(4):1564-70
pubmed: 20145099
J Clin Microbiol. 2000 Nov;38(11):4121-5
pubmed: 11060078
Int J Mol Sci. 2017 May 11;18(5):
pubmed: 28492466
J Neuroimmunol. 2006 May;174(1-2):92-100
pubmed: 16519950
Neuroscience. 2008 Jan 2;151(1):63-73
pubmed: 18055122
Cell Signal. 2010 Oct;22(10):1437-47
pubmed: 20566383
J Mol Neurosci. 2013 Jul;50(3):600-7
pubmed: 23625270
Sci Rep. 2016 Jun 02;6:27171
pubmed: 27251195
J Immunol. 2009 Mar 15;182(6):3775-81
pubmed: 19265156
Peptides. 1996;17(7):1097-105
pubmed: 8959742
Bioessays. 2011 Sep;33(9):693-700
pubmed: 21773979
Mult Scler. 2004 Dec;10(6):651-9
pubmed: 15584490
Int J Parasitol. 2014 Feb;44(2):85-90
pubmed: 24184911
J Anat. 2003 Jul;203(1):1-19
pubmed: 12892403
Crit Rev Oral Biol Med. 2002;13(3):229-37
pubmed: 12090463
J Immunol. 1999 Apr 15;162(8):4685-96
pubmed: 10202009
J Mol Neurosci. 2018 Sep;66(1):102-113
pubmed: 30105629
J Neuroimmunol. 2007 Jan;182(1-2):13-21
pubmed: 17046071
Front Immunol. 2019 Mar 22;10:554
pubmed: 30967875
Trends Immunol. 2003 May;24(5):221-4
pubmed: 12738408
Acta Neuropathol Commun. 2016 Mar 16;4:25
pubmed: 26984535
J Neurosci Res. 2007 Jul;85(9):2017-25
pubmed: 17492795
Curr Opin Immunol. 2010 Aug;22(4):461-6
pubmed: 20537517
Cell Microbiol. 2014 Apr;16(4):580-95
pubmed: 24245749
Neuron. 2015 Jul 15;87(2):341-54
pubmed: 26119026
J Clin Microbiol. 1989 Aug;27(8):1787-92
pubmed: 2768467
J Immunol. 2001 Jul 15;167(2):966-75
pubmed: 11441105
J Immunol. 2013 Nov 1;191(9):4665-75
pubmed: 24078688
Cell Signal. 2006 Feb;18(2):162-73
pubmed: 15993038

Auteurs

Caio Andreeta Figueiredo (CA)

Medical Faculty, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Henning Peter Düsedau (HP)

Medical Faculty, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Johannes Steffen (J)

Medical Faculty, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Nishith Gupta (N)

Faculty of Life Sciences, Institute of Biology, Humboldt University, Berlin, Germany.

Miklos Pal Dunay (MP)

Department and Clinic of Surgery and Ophthalmology, University of Veterinary Medicine, Budapest, Hungary.

Gabor K Toth (GK)

Department of Medical Chemistry, University of Szeged, Szeged, Hungary.

Dora Reglodi (D)

Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, Pecs, Hungary.

Markus M Heimesaat (MM)

Department of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.

Ildiko Rita Dunay (IR)

Medical Faculty, Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Center for Behavioral Brain Sciences - CBBS, Magdeburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes Ly › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Immunomodulatory Effects of the Neuropeptide...
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questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Immunomodulatory Effects of the Neuropeptide...
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questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Immunomodulatory Effects of the Neuropeptide...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs au polypeptide activateur de l'adénylcyclase hypophysaire › Récepteur au peptide intestinal vasoactif (VIP) et au PACAP › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs au polypeptide activateur de l'adénylcyclase hypophysaire › Récepteur de type I au peptide intestinal vasoactif › Immunomodulatory Effects of the Neuropeptide...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Coccidia › Eimeriida › Sarcocystidae › Toxoplasma › Immunomodulatory Effects of the Neuropeptide...
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