Complement, infection, and autoimmunity.


Journal

Current opinion in rheumatology
ISSN: 1531-6963
Titre abrégé: Curr Opin Rheumatol
Pays: United States
ID NLM: 9000851

Informations de publication

Date de publication:
09 2019
Historique:
pubmed: 14 6 2019
medline: 26 5 2020
entrez: 14 6 2019
Statut: ppublish

Résumé

Complement system dysfunction in terms of upregulation, downregulation, or dysregulation can create an imbalance of both host defense and inflammatory response leading to autoimmunity. In this review, we aimed at describing the role of complement system in host defense to inflection and in autoimmunity starting from the evidence from primary and secondary complement system deficiencies. Complement system has a determinant role in defense against infections: deficiencies of complement components are associated with increased susceptibility to infections. Primary complement system deficiencies are rare disorders that predispose to both infections and autoimmune diseases. Secondary complement system deficiencies are the result of the complement system activation with consumption. Complement system role in enhancing risk of infective diseases in secondary deficiencies has been demonstrated in patients affected by systemic autoimmune disorders, mainly systemic lupus erythematosus and vasculitis. The relationship between the complement system and autoimmunity appears paradoxical as both the deficiency and the activation contribute to inducing autoimmune diseases. In these conditions, the presence of complement deposition in affected tissues, decreased levels of complement proteins, and high levels of complement activation fragments in the blood and vessels have been documented.

Identifiants

pubmed: 31192812
doi: 10.1097/BOR.0000000000000633
doi:

Substances chimiques

Complement System Proteins 9007-36-7

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

532-541

Auteurs

Paola Conigliaro (P)

Department of Systems Medicine, Rheumatology, Allergology and Clinical Immunology, University of Rome Tor Vergata.

Paola Triggianese (P)

Department of Systems Medicine, Rheumatology, Allergology and Clinical Immunology, University of Rome Tor Vergata.

Eleonora Ballanti (E)

Department of Systems Medicine, Rheumatology, Allergology and Clinical Immunology, University of Rome Tor Vergata.

Carlo Perricone (C)

Dipartimento Medicina Interna e Specialità Mediche, Lupus Clinic, Reumatologia, Sapienza Università di Roma, Rome, Italy.

Roberto Perricone (R)

Department of Systems Medicine, Rheumatology, Allergology and Clinical Immunology, University of Rome Tor Vergata.

Maria Sole Chimenti (MS)

Department of Systems Medicine, Rheumatology, Allergology and Clinical Immunology, University of Rome Tor Vergata.

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Classifications MeSH