The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes.
Apnea–hypopnea index (AHI)
BMD, bone mineral density
BMD/TBS
BMI, body mass index
CV, coefficient of variation
DXA, dual-energy X-ray absorptiometry
FN, femoral neck
Gender
HRpQCT, high resolution peripheral quantitative computed tomography
HbA1c, hemoglobin A1c
IQR, interquartile range
ISCD, International Society for Clinical Densitometry
L1-4, lumbar spine 1-4
Menopausal status
OSA, obstructive sleep apnea
Obstructive sleep apnea
PMW, postmenopausal women
RMS, root mean square
SD, standard deviation
T2DM, type 2 diabetes mellitus
TBS, trabecular bone score
Type 2 diabetes
aBMD, areal bone mineral density
min O2, minimum O2
p, peripheral arterial tone (PAT)
pAHI, PAT-derived apnea hypopnia index
pODI, PAT-derived oxygen desaturation index
pT90, PAT-derived T90
Journal
Journal of clinical & translational endocrinology
ISSN: 2214-6237
Titre abrégé: J Clin Transl Endocrinol
Pays: Netherlands
ID NLM: 101629335
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
07
03
2019
revised:
12
04
2019
accepted:
01
05
2019
entrez:
14
6
2019
pubmed:
14
6
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) may adversely affect bone. Gender is a well-established factor influencing bone health. We investigated the impact of OSA on bone mineral density (BMD) and trabecular bone score (TBS) in T2DM. Eighty-one T2DM patients [33 men and 48 women] participated. OSA was diagnosed using an overnight monitor, with its severity assessed by an apnea hypopnia index (pAHI). The measurements of hypoxia, including the percentage of total sleep time in which oxygen saturation remains below 90% (pT90), the oxygen desaturation index (pODI) and minimum O Sixty-five patients (80.2%) had OSA. pAHI, pT90, pODI and min O In T2DM patients, there is a complex interrelationship among OSA severity, gender and TBS. More severe OSA predicted lower TBS in men, but predicted higher TBS in postmenopausal women.
Identifiants
pubmed: 31193067
doi: 10.1016/j.jcte.2019.100193
pii: S2214-6237(19)30031-6
pii: 100193
pmc: PMC6514725
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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