Insights into the biology of fibrodysplasia ossificans progressiva using patient-derived induced pluripotent stem cells.
Disease modeling
Drug discovery
Fibrodysplasia ossificans progressiva
Induced pluripotent stem cell
Rapamycin
Journal
Regenerative therapy
ISSN: 2352-3204
Titre abrégé: Regen Ther
Pays: Netherlands
ID NLM: 101709085
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
29
01
2019
revised:
18
03
2019
accepted:
05
04
2019
entrez:
14
6
2019
pubmed:
14
6
2019
medline:
14
6
2019
Statut:
epublish
Résumé
The demand for development of new drugs remains on the upward trend because of the large number of patients suffering from intractable diseases for which effective treatment has not been established yet. Recently, several researchers have attempted to apply induced pluripotent stem cell (iPSC) technology as a powerful tool for studying the mechanisms underlying the onset of various diseases and for new drug screening. This technology has made an enormous breakthrough, since it permits us to recapitulate the disease phenotype
Identifiants
pubmed: 31193176
doi: 10.1016/j.reth.2019.04.004
pii: S2352-3204(19)30014-8
pmc: PMC6517845
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
25-30Références
J Health Econ. 1991 Jul;10(2):107-42
pubmed: 10113009
Pharmacoeconomics. 1995 Feb;7(2):152-69
pubmed: 10155302
Development. 2000 Apr;127(8):1671-9
pubmed: 10725243
Dev Biol. 2002 Jan 1;241(1):106-16
pubmed: 11784098
J Health Econ. 2003 Mar;22(2):151-85
pubmed: 12606142
Nat Rev Drug Discov. 2004 Aug;3(8):673-83
pubmed: 15286734
J Anat. 2005 Nov;207(5):575-601
pubmed: 16313393
Dev Dyn. 2006 May;235(5):1310-25
pubmed: 16395689
Health Aff (Millwood). 2006 Mar-Apr;25(2):420-8
pubmed: 16522582
Nat Genet. 2006 May;38(5):525-7
pubmed: 16642017
Clin Med (Lond). 2006 Mar-Apr;6(2):163-5
pubmed: 16688974
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
Ann N Y Acad Sci. 2007 Nov;1116:113-33
pubmed: 17872396
J Bone Miner Res. 2008 Mar;23(3):305-13
pubmed: 17967130
Nat Chem Biol. 2008 Jan;4(1):33-41
pubmed: 18026094
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
Nat Biotechnol. 2007 Dec;25(12):1468-75
pubmed: 18037878
Best Pract Res Clin Rheumatol. 2008 Mar;22(1):191-205
pubmed: 18328989
Science. 2008 Aug 29;321(5893):1218-21
pubmed: 18669821
J Biol Chem. 2009 Mar 13;284(11):7149-56
pubmed: 18684712
Cell. 2008 Sep 5;134(5):877-86
pubmed: 18691744
Biochem Biophys Res Commun. 2008 Dec 19;377(3):905-9
pubmed: 18952055
Nat Med. 2008 Dec;14(12):1363-9
pubmed: 19029982
Hum Mutat. 2009 Mar;30(3):379-90
pubmed: 19085907
Health Econ. 2010 Feb;19(2):130-41
pubmed: 19247981
J Clin Invest. 2009 Nov;119(11):3462-72
pubmed: 19855136
J Bone Miner Res. 2010 Jun;25(6):1208-15
pubmed: 19929436
Nat Rev Drug Discov. 2010 Mar;9(3):203-14
pubmed: 20168317
J Biol Chem. 2010 Jul 16;285(29):22542-53
pubmed: 20463014
Nature. 2010 Sep 16;467(7313):285-90
pubmed: 20644535
Nat Rev Rheumatol. 2010 Sep;6(9):518-27
pubmed: 20703219
Health Policy. 2011 Apr;100(1):4-17
pubmed: 21256615
Biochem Biophys Res Commun. 2011 Apr 1;407(1):213-8
pubmed: 21377447
Clin Pharmacol Ther. 2011 May;89(5):655-61
pubmed: 21430656
Nat Med. 2011 Apr;17(4):454-60
pubmed: 21460849
Dev Dyn. 2012 Jan;241(1):200-14
pubmed: 22174087
Drug Discov Today Ther Strateg. 2011 Winter;8(3-4):61-69
pubmed: 22368688
Nat Rev Drug Discov. 2012 Mar 01;11(3):191-200
pubmed: 22378269
J Bone Miner Res. 2012 Aug;27(8):1746-56
pubmed: 22508565
Sci Rep. 2012;2:455
pubmed: 22701159
FEBS Lett. 2012 Jul 4;586(14):1846-59
pubmed: 22710174
Stem Cells. 2012 Nov;30(11):2437-49
pubmed: 22949078
J Biol Chem. 2012 Oct 26;287(44):36990-8
pubmed: 22977237
Dis Model Mech. 2012 Nov;5(6):756-62
pubmed: 23115204
Nat Protoc. 2013 Jan;8(1):203-12
pubmed: 23288320
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12
pubmed: 23401516
BMJ Open. 2013 Feb 20;3(2):null
pubmed: 23427198
Mol Cell Biol. 2013 Jun;33(12):2413-24
pubmed: 23572558
Curr Med Chem. 2013;20(23):2839-60
pubmed: 23651302
Development. 2013 Jun;140(12):2457-61
pubmed: 23715538
Cell Stem Cell. 2013 Jun 6;12(6):656-68
pubmed: 23746975
Pediatr Endocrinol Rev. 2013 Jun;10 Suppl 2:437-48
pubmed: 23858627
Bone. 2013 Dec;57(2):386-91
pubmed: 24051199
Orphanet J Rare Dis. 2013 Dec 09;8:190
pubmed: 24321451
Stem Cells. 2014 May;32(5):1289-300
pubmed: 24449086
EMBO J. 2014 Mar 3;33(5):409-17
pubmed: 24500035
Exp Cell Res. 2014 Jul 15;325(2):138-47
pubmed: 24509233
Science. 2014 Mar 14;343(6176):1253-6
pubmed: 24626928
Development. 2014 Jul;141(14):2848-54
pubmed: 24948603
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1167-72
pubmed: 25092317
Nature. 2014 Sep 25;513(7519):507-11
pubmed: 25231866
PLoS One. 2014 Dec 02;9(12):e112291
pubmed: 25464501
Stem Cells. 2015 Jun;33(6):1730-42
pubmed: 25773749
Stem Cell Reports. 2015 Apr 14;4(4):712-26
pubmed: 25818812
J Anat. 2015 Oct;227(4):418-30
pubmed: 26249743
Sci Transl Med. 2015 Sep 2;7(303):303ra137
pubmed: 26333933
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15438-43
pubmed: 26621707
Development. 2016 Jan 15;143(2):339-47
pubmed: 26657771
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47
pubmed: 26721400
Clin Trials. 2016 Apr;13(2):117-26
pubmed: 26908540
J Bone Miner Res. 2016 Mar;31(3):650-6
pubmed: 27025942
Cell. 2016 Jul 14;166(2):451-467
pubmed: 27419872
Cell Rep. 2017 Jan 3;18(1):68-81
pubmed: 28052261
Sci Transl Med. 2017 May 24;9(391):
pubmed: 28539470
J Clin Invest. 2017 Sep 1;127(9):3339-3352
pubmed: 28758906
Development. 2018 Aug 23;145(16):
pubmed: 30139810
Stem Cell Reports. 2018 Nov 13;11(5):1106-1119
pubmed: 30392977
J Vis Exp. 2019 Apr 25;(146):null
pubmed: 31081810
Science. 1988 Dec 16;242(4885):1528-34
pubmed: 3201241
Science. 1965 Nov 12;150(3698):893-9
pubmed: 5319761
Dev Biol. 1983 Mar;96(1):144-65
pubmed: 6825950
Nat Med. 1995 Nov;1(11):1122-5
pubmed: 7584975