Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants.
2′-fucosyllactose (2′FL)
3′-sialyllactose (3′SL)
Lewis
disialyllacto-N-tetraose (DSLNT)
human milk oligosaccharides (HMO)
lactation
milk group
preterm
secretor
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
05 Jun 2019
05 Jun 2019
Historique:
received:
09
05
2019
revised:
28
05
2019
accepted:
04
06
2019
entrez:
15
6
2019
pubmed:
15
6
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Human milk oligosaccharides (HMOs) are a major component of human milk, and play an important role in protecting the infant from infections. Preterm infants are particularly vulnerable, but have improved outcomes if fed with human milk. This study aimed to determine if the HMO composition of preterm milk differed from that of term milk at equivalent stage of lactation and equivalent postmenstrual age. In all, 22 HMOs were analyzed in 500 samples of milk from 25 mothers breastfeeding very preterm infants (< 32 weeks of gestational age, < 1500g of birthweight) and 28 mothers breastfeeding term infants. The concentrations of most HMOs were comparable at equivalent postpartum age. However, HMOs containing α-1,2-linked fucose were reduced in concentration in preterm milk during the first month of lactation. The concentrations of a number of sialylated oligosaccharides were also different in preterm milk, in particular 3'-sialyllactose concentrations were elevated. At equivalent postmenstrual age, the concentrations of a number of HMOs were significantly different in preterm compared to term milk. The largest differences manifest around 40 weeks of postmenstrual age, when the milk of term infants contains the highest concentrations of HMOs. The observed differences warrant further investigation in view of their potential clinical impact.
Identifiants
pubmed: 31195757
pii: nu11061282
doi: 10.3390/nu11061282
pmc: PMC6627155
pii:
doi:
Substances chimiques
Oligosaccharides
0
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
S.A., C.A.D.C., N.S., A.B., M.A., and C.L.G.R. are all employees of Nestec Ltd. L.B., J.F.T. and C.J.F.F. declare no conflict of interest.
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