Radiological assessment of mandibular invasion in squamous cell carcinoma of the oral cavity and oropharynx.
Carcinoma, Squamous Cell
/ mortality
Female
Humans
Magnetic Resonance Imaging
Male
Mandible
/ diagnostic imaging
Middle Aged
Mouth Neoplasms
/ mortality
Neoplasm Invasiveness
Oropharyngeal Neoplasms
/ mortality
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity
Tomography, X-Ray Computed
Computed tomography
Magnetic resonance imaging
Mandibular bone invasion
Oropharyngeal and oral cavity cancer
Sensitivity and specificity
Journal
European annals of otorhinolaryngology, head and neck diseases
ISSN: 1879-730X
Titre abrégé: Eur Ann Otorhinolaryngol Head Neck Dis
Pays: France
ID NLM: 101531465
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
pubmed:
15
6
2019
medline:
18
3
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
Preoperative assessment of mandibular bone invasion in squamous cell carcinoma of the oral cavity and oropharynx is crucial for optimizing bone resection. The principal aim of this study was to evaluate the diagnostic value of CT and MR imaging for the diagnosis of mandibular bone invasion compared to the histological reference. In addition, we assessed the survival impact of bone invasion. A single-center retrospective study included all consecutive patients treated by mandibular bone interruption for squamous cell carcinoma of the oral cavity and/or oropharynx. Sixty-eight patients were included. Prevalence of bone invasion on histology was 43%. Sensitivity, specificity and positive and negative predictive value were respectively 70%, 71%, 66% and 76% for CT compared with histologic analysis, 83%, 50%, 59% and 78% for MRI, and 83%, 62% 62%, 83% for associated CT and MRI. The two tests showed good agreement, with kappa index 0.69 (95% CI, 0.49-0.89) (P<0.0001). There was no difference in overall survival (log-rank>0.70) between the groups with and without bone invasion. CT and MRI are complementary for preoperative assessment of mandibular bone invasion, be it cortical and/or medullary, and in some cases may allow mandibular bone-sparing.
Sections du résumé
BACKGROUND
BACKGROUND
Preoperative assessment of mandibular bone invasion in squamous cell carcinoma of the oral cavity and oropharynx is crucial for optimizing bone resection. The principal aim of this study was to evaluate the diagnostic value of CT and MR imaging for the diagnosis of mandibular bone invasion compared to the histological reference. In addition, we assessed the survival impact of bone invasion.
PATIENTS AND METHODS
METHODS
A single-center retrospective study included all consecutive patients treated by mandibular bone interruption for squamous cell carcinoma of the oral cavity and/or oropharynx.
RESULTS
RESULTS
Sixty-eight patients were included. Prevalence of bone invasion on histology was 43%. Sensitivity, specificity and positive and negative predictive value were respectively 70%, 71%, 66% and 76% for CT compared with histologic analysis, 83%, 50%, 59% and 78% for MRI, and 83%, 62% 62%, 83% for associated CT and MRI. The two tests showed good agreement, with kappa index 0.69 (95% CI, 0.49-0.89) (P<0.0001). There was no difference in overall survival (log-rank>0.70) between the groups with and without bone invasion.
CONCLUSION
CONCLUSIONS
CT and MRI are complementary for preoperative assessment of mandibular bone invasion, be it cortical and/or medullary, and in some cases may allow mandibular bone-sparing.
Identifiants
pubmed: 31196801
pii: S1879-7296(19)30095-X
doi: 10.1016/j.anorl.2019.05.005
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
361-366Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.