HIF-1α is required for development of the sympathetic nervous system.

Adrenal Medulla / embryology Animals Chromaffin Cells Coronary Vessel Anomalies / embryology Coronary Vessels / embryology Female Ganglia, Sympathetic / embryology Heart / embryology Hypoxia-Inducible Factor 1, alpha Subunit / physiology Male Mice Mice, Knockout Mice, Transgenic Sympathetic Nervous System / enzymology
cardiac innervation coronary artery branching hypoxia sympathetic neurons tyrosine hydroxylase

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
02 07 2019
Historique:
pubmed: 15 6 2019
medline: 31 3 2020
entrez: 15 6 2019
Statut: ppublish

Résumé

The molecular mechanisms regulating sympathetic innervation of the heart during embryogenesis and its importance for cardiac development and function remain to be fully elucidated. We generated mice in which conditional knockout (CKO) of the

Identifiants

DOI: 10.1073/pnas.1903510116 PMID: 31196952 PMC: PMC6613092
pubmed: 31196952
pii: 1903510116
doi: 10.1073/pnas.1903510116
pmc: PMC6613092
doi:

Substances chimiques

Hif1a protein, mouse 0
Hypoxia-Inducible Factor 1, alpha Subunit 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13414-13423

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Romana Bohuslavova (R)

Laboratory of Molecular Pathogenetics, Institute of Biotechnology, Czech Academy of Sciences, 252 50 Vestec, Czechia; romana.bohuslavova@ibt.cas.cz gsemenza@jhmi.edu gpavlinkova@ibt.cas.cz.

Radka Cerychova (R)

Laboratory of Molecular Pathogenetics, Institute of Biotechnology, Czech Academy of Sciences, 252 50 Vestec, Czechia.

Frantisek Papousek (F)

Institute of Physiology, Czech Academy of Sciences, 142 00 Prague, Czechia.

Veronika Olejnickova (V)

Institute of Physiology, Czech Academy of Sciences, 142 00 Prague, Czechia.
Institute of Anatomy, First Faculty of Medicine, Charles University, 110 00 Prague, Czechia.

Martin Bartos (M)

Institute of Anatomy, First Faculty of Medicine, Charles University, 110 00 Prague, Czechia.
Institute of Dental Medicine, First Faculty of Medicine, Charles University, 110 00 Prague, Czechia.

Agnes Görlach (A)

German Heart Centre Munich, Technical University, 80636 Munich, Germany.
German Centre for Cardiovascular Research, Partner Site Munich, Munich Heart Alliance, 80636 Munich, Germany.

Frantisek Kolar (F)

Institute of Physiology, Czech Academy of Sciences, 142 00 Prague, Czechia.

David Sedmera (D)

Institute of Physiology, Czech Academy of Sciences, 142 00 Prague, Czechia.
Institute of Anatomy, First Faculty of Medicine, Charles University, 110 00 Prague, Czechia.

Gregg L Semenza (GL)

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; romana.bohuslavova@ibt.cas.cz gsemenza@jhmi.edu gpavlinkova@ibt.cas.cz.
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Gabriela Pavlinkova (G)

Laboratory of Molecular Pathogenetics, Institute of Biotechnology, Czech Academy of Sciences, 252 50 Vestec, Czechia; romana.bohuslavova@ibt.cas.cz gsemenza@jhmi.edu gpavlinkova@ibt.cas.cz.

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Classifications MeSH

questionsmedicales.fr › Système endocrine › Glandes endocrines › Glandes surrénales › Médulla surrénale › HIF-1α is required for development of the...
questionsmedicales.fr › Eucaryotes › Animaux › HIF-1α is required for development of the...
questionsmedicales.fr › Cellules › Cellules chromaffines › HIF-1α is required for development of the...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations cardiovasculaires › Cardiopathies congénitales › Anomalies congénitales des vaisseaux coronaires › HIF-1α is required for development of the...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Veines › Vaisseaux coronaires › HIF-1α is required for development of the...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux sympathique › Ganglions sympathiques › HIF-1α is required for development of the...
questionsmedicales.fr › Système cardiovasculaire › Coeur › HIF-1α is required for development of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteur-1 induit par l'hypoxie › Sous-unité alpha du facteur-1 induit par l'hypoxie › HIF-1α is required for development of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › HIF-1α is required for development of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › HIF-1α is required for development of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › HIF-1α is required for development of the...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux sympathique › HIF-1α is required for development of the...