Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke.
Animals
Brain Infarction
/ physiopathology
Forelimb
/ physiopathology
Lateral Ventricles
/ physiopathology
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neurogenesis
/ physiology
Neuroglia
/ physiology
Neuronal Plasticity
/ physiology
Neurons
/ physiology
Recovery of Function
/ physiology
Stroke
/ physiopathology
astrocyte
motor
neurorehabilitation
plasticity
synapse
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
02 07 2019
02 07 2019
Historique:
pubmed:
15
6
2019
medline:
31
3
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
Stroke is the leading cause of adult disability. Neurogenesis after stroke is associated with repair; however, the mechanisms regulating poststroke neurogenesis and its functional effect remain unclear. Here, we investigate multiple mechanistic routes of induced neurogenesis in the poststroke brain, using both a forelimb overuse manipulation that models a clinical neurorehabilitation paradigm, as well as local manipulation of cellular activity in the peri-infarct cortex. Increased activity in the forelimb peri-infarct cortex via either modulation drives increased subventricular zone (SVZ) progenitor proliferation, migration, and neuronal maturation in peri-infarct cortex. This effect is sensitive to competition from neighboring brain regions. By using orthogonal tract tracing and rabies virus approaches in transgenic SVZ-lineage-tracing mice, SVZ-derived neurons synaptically integrate into the peri-infarct cortex; these effects are enhanced with forelimb overuse. Synaptic transmission from these newborn SVZ-derived neurons is critical for spontaneous recovery after stroke, as tetanus neurotoxin silencing specifically of the SVZ-derived neurons disrupts the formation of these synaptic connections and hinders functional recovery after stroke. SVZ-derived neurogenesis after stroke is activity-dependent, region-specific, and sensitive to modulation, and the synaptic connections formed by these newborn cells are functionally critical for poststroke recovery.
Identifiants
pubmed: 31196958
pii: 1811825116
doi: 10.1073/pnas.1811825116
pmc: PMC6612913
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13621-13630Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Nat Neurosci. 1999 Mar;2(3):266-70
pubmed: 10195220
J Neurosci. 2002 Apr 1;22(7):2679-89
pubmed: 11923433
Nat Med. 2002 Sep;8(9):963-70
pubmed: 12161747
Neurosci Lett. 2002 Nov 22;333(2):123-6
pubmed: 12419496
Neuron. 2004 May 27;42(4):553-66
pubmed: 15157418
Stroke. 2004 Jul;35(7):1732-7
pubmed: 15178821
Nat Neurosci. 2004 Nov;7(11):1233-41
pubmed: 15494728
Neuron. 2005 Apr 7;46(1):103-16
pubmed: 15820697
Stem Cells. 2006 Mar;24(3):739-47
pubmed: 16210404
J Neurosci. 2005 Nov 2;25(44):10167-79
pubmed: 16267224
J Neurosci. 2006 Jun 14;26(24):6627-36
pubmed: 16775151
J Cereb Blood Flow Metab. 2007 Mar;27(3):564-74
pubmed: 16835628
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13198-202
pubmed: 16924107
Stroke. 2007 Jan;38(1):153-61
pubmed: 17122419
J Neurosci. 2006 Dec 13;26(50):13007-16
pubmed: 17167090
J Neurosci. 2006 Dec 13;26(50):13114-9
pubmed: 17167100
Neuron. 2007 Mar 1;53(5):639-47
pubmed: 17329205
Glia. 2008 Apr;56(5):481-93
pubmed: 18240313
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3581-6
pubmed: 18299565
Stroke. 2008 May;39(5):1520-5
pubmed: 18323492
Neurosci Lett. 2008 Sep 19;442(3):305-8
pubmed: 18647640
Nat Neurosci. 2008 Oct;11(10):1153-61
pubmed: 18758458
Nat Methods. 2009 Mar;6(3):219-24
pubmed: 19219033
Curr Opin Neurobiol. 2008 Dec;18(6):617-23
pubmed: 19349161
Tohoku J Exp Med. 2009 Aug;218(4):301-8
pubmed: 19638734
J Neurosci. 2009 Sep 23;29(38):11852-8
pubmed: 19776271
Nat Neurosci. 2010 Feb;13(2):173-9
pubmed: 20037576
Neurology. 2010 Feb 2;74(5):357-65
pubmed: 20054008
N Engl J Med. 2010 May 13;362(19):1772-83
pubmed: 20400552
Exp Neurol. 2010 Nov;226(1):90-9
pubmed: 20713052
Cereb Cortex. 2011 Apr;21(4):865-76
pubmed: 20739477
Neuron. 2010 Aug 26;67(4):562-74
pubmed: 20797534
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21848-53
pubmed: 21115815
PLoS One. 2011 Mar 31;6(3):e18472
pubmed: 21483754
J Neurosci. 2011 Jun 22;31(25):9205-21
pubmed: 21697371
Neurorehabil Neural Repair. 2012 Mar-Apr;26(3):282-92
pubmed: 21926382
Eur J Neurol. 2012 Apr;19(4):578-86
pubmed: 22040308
Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):E2230-9
pubmed: 22837401
Brain. 2012 Nov;135(Pt 11):3265-81
pubmed: 23169918
Stroke. 2013 Feb;44(2):483-9
pubmed: 23321442
Curr Opin Neurol. 2013 Dec;26(6):609-16
pubmed: 24136129
J Neurosci. 2013 Oct 30;33(44):17314-25
pubmed: 24174664
Cell. 2014 Feb 27;156(5):1072-83
pubmed: 24561062
Cell Rep. 2014 Apr 10;7(1):269-80
pubmed: 24656815
Nat Neurosci. 2014 Jun;17(6):801-3
pubmed: 24747576
Neuroscience. 2015 Feb 12;286:316-24
pubmed: 25463522
Lancet Neurol. 2015 Feb;14(2):224-34
pubmed: 25772900
Neuron. 2015 Mar 18;85(6):1289-304
pubmed: 25789756
Cold Spring Harb Perspect Biol. 2015 Nov 02;7(11):null
pubmed: 26525149
Front Neurosci. 2016 Apr 05;10:149
pubmed: 27092050
Ann Neurol. 2016 Sep;80(3):342-54
pubmed: 27447365
Nature. 2016 Nov 17;539(7629):428-432
pubmed: 27828941
Neuroscientist. 2017 Dec;23(6):605-615
pubmed: 28299949
Neuron. 2017 Nov 15;96(4):883-896.e7
pubmed: 29056299
Nature. 2018 Mar 15;555(7696):377-381
pubmed: 29513649
Cell Stem Cell. 2018 Apr 5;22(4):589-599.e5
pubmed: 29625071
Trends Mol Med. 2018 Jun;24(6):521-522
pubmed: 29699864