The ion channels and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma.
Aged
Cohort Studies
Databases, Genetic
Disease Progression
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Humans
Ion Channels
/ genetics
Lymphoma, Follicular
/ genetics
Lymphoma, Large B-Cell, Diffuse
/ genetics
Male
Membrane Transport Proteins
/ genetics
Middle Aged
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 06 2019
13 06 2019
Historique:
received:
30
09
2016
accepted:
21
05
2019
entrez:
15
6
2019
pubmed:
15
6
2019
medline:
21
10
2020
Statut:
epublish
Résumé
The definition of the gene expression profile of genes encoding Ion Channels and Transporters (ICT-GEP) represents a novel and attracting aspect in cancer. We determined the ICT-GEP of Follicular Lymphoma (FL), and compared it with that of the more aggressive Diffuse Large B Cell Lymphoma (DLBCL). cDNA microarray data were collected both from patients enrolled for this study, and from public datasets. In FL the ICT-GEP indicated the overexpression of both the K
Identifiants
pubmed: 31197180
doi: 10.1038/s41598-019-44661-x
pii: 10.1038/s41598-019-44661-x
pmc: PMC6565741
doi:
Substances chimiques
Ion Channels
0
Membrane Transport Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8586Références
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