Mechanisms of cellular rejuvenation.
aging
aging factors
asymmetric cell division
direct reprogramming
rejuvenation
reprogramming
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
03
04
2019
revised:
29
04
2019
accepted:
02
05
2019
pubmed:
15
6
2019
medline:
20
6
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
Aging leads to changes on an organismal but also cellular level. However, the exact mechanisms of cellular aging in mammals remain poorly understood and the identity and functional role of aging factors, some of which have previously been defined in model organisms such as Saccharomyces cerevisiae, remain elusive. Remarkably, during cellular reprogramming most if not all aging hallmarks are erased, offering a novel entry point to study aging and rejuvenation on a cellular level. On the other hand, direct reprogramming of old cells into cells of a different fate preserves many aging signs. Therefore, investigating the process of reprogramming and comparing it to direct reprogramming may yield novel insights about the clearing of aging factors, which is the basis of rejuvenation. Here, we discuss how reprogramming might lead to rejuvenation of a cell, an organ, or even the whole organism.
Identifiants
pubmed: 31197818
doi: 10.1002/1873-3468.13483
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3381-3392Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : BSCGI0_157859
Pays : International
Organisme : H2020 European Research Council
Pays : International
Organisme : Zurich Neuroscience Center (ZNZ)
Pays : International
Informations de copyright
© 2019 Federation of European Biochemical Societies.
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