Lipidomics Reveals Triacylglycerol Accumulation Due to Impaired Fatty Acid Flux in Opa1-Disrupted Fibroblasts.
dominant optic atrophy
fatty acid oxidation
lipid droplets
membrane/fusion
mitochondria
optic neuropathy
Journal
Journal of proteome research
ISSN: 1535-3907
Titre abrégé: J Proteome Res
Pays: United States
ID NLM: 101128775
Informations de publication
Date de publication:
05 07 2019
05 07 2019
Historique:
pubmed:
15
6
2019
medline:
21
7
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
OPA1 is a dynamin GTPase implicated in mitochondrial membrane fusion. Despite its involvement in lipid remodeling, the function of OPA1 has never been analyzed by whole-cell lipidomics. We used a nontargeted, reversed-phase lipidomics approach, validated for cell cultures, to investigate OPA1-inactivated mouse embryonic fibroblasts ( Opa1
Identifiants
pubmed: 31199663
doi: 10.1021/acs.jproteome.9b00081
doi:
Substances chimiques
Fatty Acids
0
Triglycerides
0
GTP Phosphohydrolases
EC 3.6.1.-
Opa1 protein, mouse
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM