Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis.
Antiviral resistance
Herpes simplex virus
Herpetic keratitis
Recombinant virus
Thymidine kinase
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
13
05
2019
revised:
06
06
2019
accepted:
10
06
2019
pubmed:
15
6
2019
medline:
13
6
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
We report here a case of an immunocompetent patient suffering from recurrent epithelial herpetic keratitis associated with the emergence of antiviral resistance. Indeed, the not previously described amino acid change L340R within herpes simplex virus thymidine kinase, was shown to confer acyclovir-resistance by recombinant phenotyping using bacmid technology.
Identifiants
pubmed: 31199933
pii: S0166-3542(19)30270-0
doi: 10.1016/j.antiviral.2019.06.007
pii:
doi:
Substances chimiques
Antiviral Agents
0
Thymidine Kinase
EC 2.7.1.21
Acyclovir
X4HES1O11F
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
183-186Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.